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This described green synthesis shows several attractive characteristics such as the use of water as reaction medium, simple reaction conditions, short reaction times and an easy work-up.

A series of new and significative bifunctional compounds containing two pyrazolo[3,4-b]pyridine moieties has been synthesized through a rapid one-pot three-component reaction of dialdehyde, 5-amino-3-methyl-1-phenylpyrazole and active methylene compounds in glycol under microwave irradiation without catalyst. The method has the advantages of good yield (85-98%), short route and reaction time (45-300s), wide reaction scope and easy work-up procedure.

A series of N-carboxymethylacridine-1,8-dione derivatives were synthesized by one-pot reaction of aldehyde, dimedone and glycine in glycol under microwave irradiation without catalyst with excellent yields (78-92%) and short reaction time (4-8min). And the reaction was not only suitable for aromatic monoaldehyde, but also aromatic dialdehyde.

Four-component cyclocondensation of aromatic aldehydes, malononitrile, dimedone and ammonium acetate proceeds under microwave irradiation in solvent free conditions to give highly functionalized hexahydroquinolines in excellent yields.

A simple and efficient synthesis of 2-amino pyrido[2,3-d]pyrimidine derivatives was accomplished via a three-component reaction under microwave irradiation without catalyst. This method had many dramatic advantages such as the short reaction time, high yield, and broad substrate scope, as well as convenient operation. We provide new series of potential biologically active compounds as inhibitors of Cdk4.

A series of 4'-aryl-2,2':6',2"-terpyridines have been prepared by the one-pot reaction of 2-acetylpyridine with aromatic aldehydes in the presence of ammonium acetate under microwave irradiation. This method has the advantages of shorter route, easier workup, shorter reaction time, higher yield and more environmentally friendly conditions, compared to the conventional ones.