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It has been shown that certain N-aryltrichoromethanesulfenamides Cl3C−S−NHAr can be dehydrochlorinated to form red-colored thiocarbonyl S-imides CCl2=S=NAr which dimerize spontaneously. The dimers ...

A series of new 2-substituted 2-methyl-4H-1,3-benzodioxin-4-ones 1 have been synthesized and fully characterized. This study involves fifteen compounds of which fourteen are orthoesters, containing tertiary aliphatic alkoxy groups. One compound contains a tert-butylperoxy group and one a 3 beta-cholesteryloxy group in the 2-position. The hydrolysis of these compounds 1 was followed in enzymatic and non-enzymatic media to clarify whether they are true prodrugs of aspirin. Two compounds 1 were additionally tested in vivo as potential topical keratolytics.

Introduction of fluorine into 4-chlorobenzyl chloromethyl sulfide (7) by crown-ether-assisted nucleophilic substitution furnishes 4-chlorobenzyl fluoromethyl sulfide (5), a key intermediate for the preparation of fluoromethanesulfonyl chloride (1).

Data on the synthesis, reactivity, physico-chemical properties, and biological activity of divinyl disulfides and of related derivatives of thiamine (vitamin B1) have been collected and are briefly discussed.

The reaction of N-(4-methylphenyl)-trichloromethanesulfenamide 2a with base gives 2,3-bis-(4-methylphenyl)-5,5,6,6,-tetrachloro-2,3,5,6-tetrahydro-1,4,2,3,-dithiadiazine 6a, which can be cleaved with HCl to give 1,1,2,2-tetrachloro-1,2-ethanedisulfenyl chloride 7, and not, respectively, 2,5-bis-(4-methylphenyl)-3,3,6,6-tetrachloro-2,3,5,6-tetrahydro-1,4,2,5-dithiadiazine 4a and trichloromethanethiol 5.

This review is concerned with the synthesis, structure, physico-chemical properties and reactivity of 3-cyanopyridin-2(1H)-ones, -thiones, and -selenones and their derivatives. The 3-cyanopyridin-2(1H)-ones, -thiones, and -selenones being bifunctional compounds containing nitrile and amide, thioamide, or selenoamide groups with an endocyclic nitrogen atom are widely used in the synthesis of different classes of annelated heterocycles possessing practically important properties.

Two new chlorodithioformates 2, six new C-sulfonyldithioformates 3, ten new chloromethanesulfenyl chlorides 4, and nineteen new C-sulfonyldithioformate S-imides 5 have been prepared. Together with analogous known compounds they were fully characterized by spectroscopic means (IR, UV VIS, MS, 1C and 13C NMR). According to these data and additional X-ray crystallographic structure determinations of selected 5 all known 5 possess the (E)-configuration and no evidence for the presence of isomeric (Z)-5 could be found.

This review is a complete and detailed account of synthetic pathways to the known naturally occurring and biologically active sulfinic acids (and their unnatural enantiomers) with additional complete references to their radiolabeled analogs.

This review is the first exhaustive account of the preparation and synthetic application of chlorodithioformates, based on a CAS Online search. 106 compounds are presented and 187 literature references included.

The synthesis and the properties of α,β-unsaturated isothiocyanates are described with 276 literature references.

The chemistry of geminal disulfenyl dichlorides R1R2C(SCl)2 is reviewed based on CAS and Beilstein Online substructure and supplementary searches.

The Thiosulfine-Dithiirane-Dithioester Manifold (TDDM) is described in detail, based on both theoretical and experimental findings, and its implications for synthetic organic chemistry discussed. Results of numerous new quantum chemical calculations obtained at the hybrid HF/DFT and beyond-HF ab initio level are reported, focusing particular attention upon the structure and the properties of thiosulfines.

The sterically crowded 2,2,4,4-tetramethyl-3-thioxocyclobutanone (7) and its dithio analogue 9 were found to react readily with gaseous chlorine to afford 1:1 and 1:2 adducts, respectively. The stable, crystalline products were identified as the α-chlorosulfenyl chlorides 8 and 12 which yielded corresponding disulfides after treatment with equimolar amounts of thioacetic acid.

C-Sulfonyldithioformates (2) (R-1 = ArSO2, R 2 = ArS) readily add to anthracene and 9-methylanthracene (1) in a Diels-Alder fashion with formation of 9,10-dihydro-10,9-(epithiomethano)anthracenes ( ...