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1. ChemInform Abstract: An Efficient Four-Component Approach for the Synthesis of Novel 5-Methyl-4-(2- (3-methyl-4-nitroisoxazol-5-yl)-1-arylethyl)-1H-pyrazol-3-ol Derivatives and Their Antibacterial Study

Author

L. Chandrasekhara Rao, S. K. Misra, Narmada Muthineni, L. Raju Chowhan, V. Dileep Kumar, Nandigama Satish Kumar, and Harshadas M. Meshram

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Organocatalysis, Ethyl acetoacetate, Yield (chemistry), Hydrazine, General Medicine, Piperidine, Hydrate, Aldehyde, Medicinal chemistry, Domino
Abstract

A One pot four-component domino reactions were developed for the synthesis of 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)-1-arylethyl)-1H-pyrazol-3-ols derivatives in excellent yield from hydrazine hydrate (1), ethyl acetoacetate (2), aldehyde (3) and 3,5-dimethyl-4-nitro-isoxazole (4) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C−C, one C−N, one O−H and one C=N) in a single step. These novel 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)-1-arylethyl)-1H-pyrazol-3-ol derivatives are evaluated as anti-bacterial agents.

Published
2016
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