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Your search keyword '"Ronald L. Cerny"' showing total 9 results
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9 results on '"Ronald L. Cerny"'

1. ChemInform Abstract: Fluoride-Promoted Ligand Exchange in Diaryliodonium Salts

Author

Bijia Wang, ShriHarsha Uppaluri, Jayson J. Kempinger, Ronald L. Cerny, and Stephen G. DiMagno

Subjects
chemistry.chemical_compound, chemistry, Ligand, Aryl, General Medicine, Acetonitrile, Fluoride, Medicinal chemistry
Abstract

Diaryliodinium salts undergo rapid, fluoride-promoted aryl ligand exchange reaction in acetonitrile at room temperature.

Published
2011
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2. ChemInform Abstract: Synthesis and Structure Determination of the Adducts of the Potent Carcinogen 7,12-Dimethylbenz(a)anthracene and Deoxyribonucleosides Formed by Electrochemical Oxidation: Models for Metabolic Activation by One-Electron Oxidation

Author

N. V. S. RamaKrishna, Eleanor G. Rogan, Ercole L. Cavalieri, Michael L. Gross, Ryszard Jankowiak, Ronald L. Cerny, H. Jeong, G. Dolnikowski, and Gerald J. Small

Subjects
Anthracene, chemistry.chemical_compound, Deoxyribonucleosides, chemistry, 7,12-Dimethylbenz[a]anthracene, Nucleic acid, Organic chemistry, General Medicine, Electrochemistry, Medicinal chemistry, Carcinogen, Derivative (chemistry), Adduct
Abstract

Anodic oxidation of 7,12-dimethylbenz[a]anthracene (7,12-DMBA) in the presence of dG yields four adducts and one oxygenated derivative of 7,12-DMBA: 7-methylbenz[a]anthracene (MBA)-12-CH 2 -C8dG (13%), 7-MBA-12-CH 2 -N7Gua (55%), 12-MBA-7-CH 2 -N7Gua (12%), 7-MBA-12-CH 2 -C8Gua (10%), and 7,12-(CH 2 OH) 2 -BA (10%). The first three are primary products of the electrochemical reaction, whereas the last two are secondary products

Published
2010
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5. ChemInform Abstract: Chrysochlamic Acid, a New Diterpenoid-Substituted Quinol from Chrysochlamys ulei that Inhibits DNA Polymerase β

Author

John R. Engen, Shelley R. Starck, Ronald L. Cerny, Jing-Zhen Deng, Di-An Sun, and Sidney M. Hecht

Subjects
biology, ved/biology, Chemistry, DNA polymerase, Stereochemistry, ved/biology.organism_classification_rank.species, General Medicine, Fractionation, biology.organism_classification, Terpenoid, Chrysochlamys, Terpene, Prenylation, Terrestrial plant, biology.protein, IC50
Abstract

Chrysochlamic acid (1), a new DNA polymerase β inhibitor having an IC50 of 4.3 µM, has been isolated from Chrysochlamys ulei through bioassay-guided fractionation; it is the first example of a prenyl m-methylhydroquinone occurring in a higher terrestrial plant.

Published
2010
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8. ChemInform Abstract: Synthesis and Identification of Benzo(a)pyrene-Guanine Nucleoside Adducts Formed by Electrochemical Oxidation and by Horseradish Peroxidase Catalyzed Reaction of Benzo(a)pyrene with DNA

Author

Michael L. Gross, Eleanor G. Rogan, Kenneth B. Tomer, C. D. Warner, S. R. Tibbels, Donald Nagel, Ercole L. Cavalieri, Paolo Cremonesi, and Ronald L. Cerny

Subjects
chemistry.chemical_compound, biology, Benzo(a)pyrene, Chemistry, biology.protein, Guanine nucleoside, General Medicine, Electrochemistry, Horseradish peroxidase, Combinatorial chemistry, DNA, Catalysis, Adduct
Published
1988
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