Search

Your search keyword '"Robert F. Rando"' showing total 4 results
Start Over Author "Robert F. Rando" Journal cheminform
4 results on '"Robert F. Rando"'

3. ChemInform Abstract: Synthesis and in vitro Anti-Human Cytomegalovirus (HCMV) Activity of Certain Alkenyl Substituted Cytosines and 5-Halocytosines

Author

Arthur F. Lewis, Ganapathi R. Revankar, and Robert F. Rando

Subjects
Human cytomegalovirus, chemistry.chemical_compound, chemistry, Stereochemistry, medicine, General Medicine, medicine.disease, In vitro, Cytosine, Sodium salt
Abstract

The 1-[(Z)-2-penten-1-yl] and 1-(3-methyl-2-buten-1-yl) derivatives of cytosine, 5-bromocytosine, 5-fluorocytosine, and 5-iodocytosine were prepared by a reaction of the sodium salt of the requisite cytosine with (Z)-1-bromo-2-pentene and 4-bromo-2-methyl-2-butene, respectively. The eight alkenylcytosines 5a-5h were evaluated in cell culture for their anti-HCMV activity. Only the derivatives of 5-bromocytosine, 5c and 5d, showed slight activity in this assay.

Published
2010
Full Text
View/download PDF

4. ChemInform Abstract: Parallel Synthesis of Isatin-Based Serine Protease Inhibitors

Author

Nola Lee, Daniel Nasturica, M. Arshad Siddiqui, Christian Gervais, Robert F. Rando, and Stephen J. Shuttleworth

Subjects
chemistry.chemical_classification, Serine, chemistry.chemical_compound, Proteases, chemistry, Isatin, Reagent, Serine Protease Inhibitors, General Medicine, Polymer, Solution synthesis, Combinatorial chemistry, Catalysis
Abstract

The synthesis of N-functionalised isatins using parallel, solution synthesis is described. Functionalised polymers were employed as stoichiometric and catalytic reagents as well as purification media in the exercise, and the derivatives were screened against a panel of serine proteases; high percentage inhibition was observed in several cases.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results