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Your search keyword '"Pietro Di Profio"' showing total 2 results
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2 results on '"Pietro Di Profio"'

1. ChemInform Abstract: Synthesis of Novel 5′-Uridine-Head Amphiphiles as Model for DNA Molecular Recognition

Author

Matteo Tiecco, Gianfranco Savelli, Raimondo Germani, and Pietro Di Profio

Subjects
chemistry.chemical_compound, Molecular recognition, chemistry, Amphiphile, Nucleic acid, Cationic polymerization, Surface modification, Uracil, General Medicine, Combinatorial chemistry, Uridine, DNA
Abstract

Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.

Published
2010
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