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15 results on '"Pagella A"'

1. ChemInform Abstract: Synthesis of Some Carbamates of myo-Inositol

Author

Gianluca Gostoli, S. Lappa, Enrico Ferrari, Mario Brufani, Luigi Filocamo, Maria C. Cesta, Pier Giuseppe Pagella, and L. Donnarumma

Subjects
chemistry.chemical_compound, Chemistry, Stereochemistry, Inositol, General Medicine, Phospholipase
Abstract

The syntheses are described of the 1-O-carbamoyl (11), 1-O-carbamoyl-2-O-stearoyl (10), 1-O-(acetylcarbamoyl)-2-O-stearoyl (12), 1-O-(heptylcarbamoyl) (13), 2-O-(heptylcarbamoyl) (14) 1,2-di-O-(heptylcarbamoyl) (15), and 1-O-(octadecylcarbamoyl) (16) derivatives of myo-inositol. None of these compounds had significant activity against phospholipase C.

Published
2010
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2. ChemInform Abstract: 1,4-Benzothiazine-2-carboxylic Acid 1-Oxides as Analogues of Antibacterial Quinolones

Author

Violetta Cecchetti, Pier Giuseppe Pagella, Fausto Schiaffella, Weicheng Zhou, Arnaldo Fravolini, and Oriana Tabarrini

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, chemistry, medicine.drug_class, Carboxylic acid, Intramolecular cyclization, medicine, Organic chemistry, General Medicine, Benzothiazine, Antibacterial activity, Quinolone
Abstract

The synthesis of 1,4-benzothiazine-2-carboxylic acid 1-oxides as agents which mimic quinolone antibacterial, are described. The key step includes intramolecular cyclization of phenylsulfinyl acrylates 17 and 18 which are prepared in six steps from 11. None of new target compounds showed interesting antibacterial activity in vitro against the tested strains.

Published
2010
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