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Your search keyword '"Nikola Burdzhiev"' showing total 4 results
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4 results on '"Nikola Burdzhiev"'

2. ChemInform Abstract: Synthesis of Novel 13a-(ω-Aminoalkyl)-8-oxoberbines by Means of Reaction of Homophthalic Anhydride with 1-Substituted 3,4-Dihydroisoquinolines. An Unexpected Formation of a Pyrrolo[3,4-i]berbindione

Author

Elena Stanoeva, László Lázár, Angelina Georgieva, Nikola Burdzhiev, and Stanislava I. Avramova

Subjects
Chemistry, General Medicine, Medicinal chemistry
Abstract

Reaction of dihydroisoquinolines (I) with homophthalic anhydride (II) results in the diastereoselective formation of cis-dibenzoquinolizinecarboxylic acids (III).

Published
2015

4. Reaction Between Glutaric Anhydride and N-Benzylidenebenzylamine, and Further Transformations to New Substituted Piperidin-2-ones

Author

Nikola Burdzhiev and Elena Stanoeva

Subjects
Reaction conditions, Piperazine, chemistry.chemical_compound, 1h nmr spectroscopy, Chemistry, Carboxylic group, Product (mathematics), Organic Chemistry, Drug Discovery, Glutaric anhydride, Organic chemistry, General Medicine, Biochemistry
Abstract

The reaction between glutaric anhydride (1) and N-benzylidenebenzylamine (3) was studied in detail by 1H NMR spectroscopy under different reaction conditions. The major product was (±)-trans-1-benzyl-6-oxo-2-phenylpiperidine-3-carboxylic acid (2), which was converted into new substituted piperidin-2-ones via transformations of the carboxylic group. The final products are expected to possess pharmaceutical activities, and the relevant screenings are in course.

Published
2006

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