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An air-assisted, functional-group-driven, mild, additive-free, three-component synthetic approach to different 2-oxo acetamidines from 2-oxo aldehydes, secondary amines, and anilines was successfully developed. Mechanistically, the transformation proceeds through a highly unstable system ((RCOCHNN2)-N-1) that rearranges at room temperature and undergoes air-assisted dehydrogenation to different 2-oxo acetamidines.

A highly efficient, novel, microwave-assisted, metal-free, diastereoselective synthesis of tetrahydrofuro[3,2-d]oxazole is disclosed. The synthesis of napthoxazoles is achieved for the first time without the aid of an external catalyst. On the contrary, our reactions generated naphthofuranones when treated in the presence of metals in microwave/thermal conditions. The unusual behavior of our reactions has further been explored in the generation of furanones from tetrahydrofuro[3,2-d]oxazole through the use of metals.

The pyrrolidine-catalyzed aerobic cross-coupling of glyoxals (I) with phenols, naphthols, indoles, and pyrroles as nucleophiles leads to diones (III) [42 examples].

Numerous glyoxals are prepared in situ from acetone (IIj), acetophenone derivatives (IIa-i) as well as other variously substituted acetophenone derivatives and subsequently transformed with tryptophane (I) to carbolines.