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Furans are an important class of compounds and exhibit a diverse range of activities and properties. As such, improved synthetic access to furans is an important research goal. In the present report, a solvent- and catalyst-free reaction between 5,5-dimethyl-1,3-cyclohexanedione (dimedone), an aryl aldehyde and an isocyanide under microwave irradiation is presented. This method is significantly improved from previously described protocols in terms of applicability of wide ranging aryl aldehydes, better yields, shorter reaction times, facile work up and essentially no need of column chromatography. The photophysical properties of this series of compounds were studied for their possible applicability in the field of metal ion sensors. In solution, two compounds, 2-(cyclohexylamino)-3-(1H-indol-3-yl)-6,6-dimethyl-6,7-dihydrobenzofuran-4(5H)-one (1 i) and 2-(tert-butylamino)-3-(1H-indol-3-yl)-6,6-dimethyl-6,7-dihydrobenzofuran-4(5H)-one (1 j), underwent an observable color change from yellow to colorless in the presence of aluminum(III) ions. Further studies to investigate the UV absorption and luminescence behavior of these compounds revealed their utility as "naked-eye sensors" for aluminum detection.

A mechanistically unprecedented approach for the formation of tertiary amides from N,N-dialkylchlorothiophosphoramidates and aldehydes has been developed. The reaction occurred via the activation of aldehydes with N,N-dialkylchlorothiophosphoramidates followed by amidation with dialkylamine pendent of the same phosphoramidate.

In the presented synthesis of the compounds (II) and (IV) aryl nitriles are the intermediates.

The reaction is conducted using an environmentally benign and simple protocol which leads to easily isolable products.

This is the first report of a facile synthesis of thiazolines and thiazines from a self-catalyzed, water assisted tandem S-alkylation-cyclodeamination reaction of thioamides/haloamines. The reaction is clean and efficient with simple product work-up, and is applicable to a variety of substrates.

A simple one-pot procedure allows the preparation of the title compounds via intermediate flavones.

substituted thioamides starting from acyl halides and amines is an attractive method as it allows an easy introduction of diverse building blocks for constructing desired thioamides. This is a two step procedure. For avoiding a lengthy separation process and purification of intermediate, one-pot preparation techniques are highly preferred. The potential of one-pot procedure is enhanced if applied with microwave heating under solvent-free condition

A very simple, environmentally benign, cost-effective, and efficient synthesis of disulfides from thiols using silica–PCl5/NaNO2 in aqueous medium has been described. The reaction was found to occur rapidly under mild conditions, and disulfides were obtained easily through a simple workup.

A convenient, highly efficient, safe microwave-mediated Salkylation of O,O’-dialkyl thiophosphate has been reported. Clean and rapid S-alkylation of thiophosphates can be achieved by irradiating a mixture of dialkylthiophosphate salt and alkyl halide under microwave for a brief period. Alkylation occurs exclusively at sulfur to provide S-alkylated products. Through a simple workup, pure compounds have been obtained easily in good yields.

A novel thionation protocol for carbonyl compounds, with the system PSCl3/H2O/Et3N has been discovered. Clean, rapid, and efficient synthesis of a variety of thiocarbonyl compounds such as thioamides, thiolactams, thioketones, thioxanthones, and thioacridone can be achieved through this simple and convenient method under solventless condition with microwave irradiation.

A new solid supported reagent, silica–PSCl3, has been developed for deoxygenation of sulfoxides. With this reagent, conversion of sulfoxides to sulfides occurred cleanly and efficiently at room temperature. Facile isolation of the product was achieved by simple filtration of the by‐products without any extensive workup.