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The reaction does not allow the use 1,1-dicyanocyclopropanes instead of 1-cyanocyclopropane-1-carboxylates.

The reaction of 1-cyanocyclopropane 1-esters (I) with pyridine as both a substrate and a solvent leads to 3-cyanoindolizines (III), whilst the reaction with an equimolar amount of pyridine in toluene as solvent affords isomeric 1-cyanoindolizines (IV).

An iodine-promoted synthesis of acylindolizinecarboxylates via 1,3-dipolar cycloaddition of nitrogen ylides with acetylenecarboxylates and subsequent aromatization for the generation of a wide range of structurally interesting, pharmacologically and photoelectrically significant compounds is reported. Only readily available materials, mild conditions, and operationally trivial reaction protocols were required.

The ratios of the substrates as well as the amount of base play a crucial role in the outcome of the reaction.

An efficient and straightforward one-pot synthetic protocol has been developed for the synthesis of 3-arylindolizine-1-carboxylates via 1,3-dipolar annulation of 2-(2-nitro-1-arylethyl)malonates wi...

A four-component synthesis of functionalized 4-hydroxybenzofurans is developed using nitrostyrenes, aromatic aldehydes, cyclohexane-1,3-diones and ammonium acetate as the reactants.

Title compounds [(IV) and (VI)] are stereoselectively synthesized via pseudo-five-component reaction.

Highly substituted title compounds of type (IV)(23 examples) are prepared with complete diastereoselectivity.