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The novel acetylene (I) shows potent inhibitory activity against LPS-induced NO production as well as strong inhibitory activities against iNOS and COX-2.

isolation, structural elucidation and antiinflammatory activity of a new megastigmane glycoside, galloyl linarionoside A (I), along with 13 known compounds

Two new compounds, erythroformide (I) and 3β-acetoxynorcassamide (II), are isolated together with four known compounds and their effects on endothelial tube formation on matrigel are investigated.

Four new lanostane triterpenes, butyl lucidenate P (I), butyl lucidenate D2 (II), butyl lucidenate E2 (III), and butyl lucidenate Q (IV), are isolated along with eleven known compounds from the fruiting bodies of Ganoderma lucidum.

Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4-guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

During the search for natural substances with PPAR-γ agonistic effect, unique polychlorinated compounds named chlorophellins A–C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis . Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-γ agonistic effect and was comparable to rosiglitazone, a well-known PPAR-γ agonist that has been used for the therapy of type 2 diabetes.