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An easy and straightforward preparation of pyrrole-embedded aza-heterocyclic scaffolds employing a Ru/B-H binary catalyst system has been developed. The strategy generates a diverse array of privileged scaffolds from 2-aminophenyl group appended pyrroles that can be prepared by a two-step process from corresponding aminoaryl-substituted pyrroles. The technique of incorporating 2-aminoaromatic groups in the heterocycles and their subsequent ring-closing-metathesis (RCM) isomerization followed by subsequent Pictet–Spengler type reaction should also be applicable to other heterocycles for generating a library of multi-ring compounds in an efficient manner.

In recent years, enantioselective cooperative catalytic reactions, wherein two catalysts work simultaneously to form products which cannot be obtained by the use of a single catalyst alone, have attracted considerable attention. This review focuses on this emerging field, with particular emphasis on mechanistic aspects, which will help readers to understand the role of each catalyst.

The research groups of Hammond/Xu and Zhang report the discovery of new ligands for gold catalysis. With these ligands, gold catalyzed reactions have been reported for a broader range of substrates with very high TONs at a level that can match the needs of large-scale applications.

This paper describes the first report in which copper species containing copper fluorapatite (CuFAP) acts as a versatile, eco-friendly, recyclable, heterogeneous catalyst for an efficient synthesis of symmetric biaryls from the homo-coupling of arylboronic acids in methanol solvent at ambient reaction conditions. The developed protocol is ligand-, base-, and co-catalyst-free, sustainable, mild, inexpensive, and compatible with a wide range of aromatic/heterocyclic boronic acids and provides the corresponding products in excellent yields without purification. The catalyst was easily recovered from the reaction mixture and reused several times without loss of activity.

A novel, highly efficient, and mild protocol has been developed for the synthesis of O -aryloxime ethers in good to excellent yields at ambient reaction conditions. This is the first report in which N O Ar linkage was achieved with ecofriendly, recyclable, heterogeneous copper fluorapatite (CuFAP) catalyst via C O cross coupling of aryloxime with arylboronic acid in the presence of Cs 2 CO 3 as base and methanol as solvent.

It is demonstrated that the condensations proceed with high efficiency in a short reaction time.

An efficient cross coupling amination of arene with azodicarboxylate to afford hydrazides catalysed by ruthenium chloride has been demonstrated. The catalyst was found to be effective across a spectrum of arenes with a variety of functional groups. The yields are found to be modest to low depending on the type of substrates. The catalyst can be recycled in ligand free conditions to afford the cross coupling reaction.

A solvent-free, environmentally clean, mild, and simple one-pot multi-component protocol has been developed for the efficient synthesis of 1-amido- and 1-carbamato-alkyl naphthols/phenols in excellent yields via one-pot three-component condensation of various aldehydes, amides/carbamates/urea, and naphthols/phenols using ethylammonium nitrate (EAN) as a reusable ionic liquid catalyst under neat reaction condition at ambient temperature.

The first report of a recyclable, heterogeneous, ecofriendly, inexpensive copper fluoroapatite catalyzed coupling reaction of phenols with arylboronic acids is described.

A wide range of aldehydes (I), including aromatic and aliphatic derivatives, is applied in the title reaction.

The method is highly effective for the coupling of aryl bromides or iodides and potassium salts of phenols (yield < 80%).

A series of 9H, 10H, 3-[ N - 4 methyl -2-benzamido thiophen 3-yl carbonyl amino [2-(2′-phenyl 1′- ethylenyl)] 10-(aryl) thiazolidino [4, 5-b] 1, 5 benzodiazepine [ 7a – 7h ] were designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Anticonvulsant activity was determined after intra-peritoneal administration to mice by supramaximal electroshock seizures model and Isoniazide Hydrazone induced seizures model. Motor impairement was determined using actophotometer and rotarod apparatus. Among the synthesized compounds two [JG 7a and JG 7e ] compounds exhibited significant anticonvulsant activity after intra-peritoneal administration. Active compounds carry hydroxy substitutent at 2-position and methoxy at 4-position in the phenyl ring at C 5 of benzodiazepine. In present we study conclude that small polar and electron rich groups contribute significantly for anticonvulsant activity while electronegative substitutents showed lesser contribution for anticonvulsant activity.