1. ChemInform Abstract: Phosphine-Catalyzed Vicinal Acylcyanation of Alkynoates
- Author
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Hirohisa Ohmiya, Hiroaki Murayama, Masaya Sawamura, and Kazunori Nagao
- Subjects
chemistry.chemical_classification ,Addition reaction ,Chemistry ,Alkene ,Regioselectivity ,General Medicine ,Triple bond ,Medicinal chemistry ,chemistry.chemical_compound ,Organocatalysis ,Moiety ,lipids (amino acids, peptides, and proteins) ,Vicinal ,Phosphine - Abstract
Phosphine organocatalysis enabled vicinal acylcyanation of alkynoates with acyl cyanides to form acrylonitrile derivatives with a tetrasubstituted alkene moiety. The acyl and cyano groups were introduced at the α and β carbon atoms, respectively, of the C–C triple bond in the alkynoates with complete regioselectivity and high anti stereoselectivity. A variety of functional groups in the acyl cyanides and alkynoates were tolerated.
- Published
- 2016
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