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21 results on '"Heinrich Steinmetz"'

1. ChemInform Abstract: Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen Paenibacillus larvae

Author

Rolf Mueller, Marc Stadler, Heinrich Steinmetz, Marvin Djukic, Kathrin I. Mohr, Werner von der Ohe, Sakshi Sood, Michael Steinert, Rolf Daniel, and Hannes Beims

Subjects
Chemistry, General Medicine, Honey bee, Isolation (microbiology), Pathogen, Microbiology, Paenibacillus larvae
Abstract

Isolation and structure elucidation of three novel iturin-type lipopeptides, paenilarvins A-C, are described.

Published
2015
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3. ChemInform Abstract: Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis. Part 1. Structural Revision and Stereochemical Assignment of Gephyronic Acid

Author

Sabine Laschat, Richard E. Taylor, R. Jansen, Heinrich Steinmetz, Timo Anderl, Lionel Nicolas, Gerhard Hoefle, and Florenz Sasse

Subjects
Archangium gephyra, Polyketide, Chemistry, Stereochemistry, Protein biosynthesis, General Medicine, Link (geometry), Gephyronic acid
Abstract

The structure of the title compound, a constituent of the myxobacterium Archangium gephyra (Ar 3895) which exists as a separable mixture of keto and hemiketal isomers, is unambiguously confirmed as (I).

Published
2011
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7. ChemInform Abstract: Antibiotics from Gliding Bacteria. Part 77. Epothilone A and B - Novel 16-Membered Macrolides with Cytotoxic Activity. Isolation, Crystal Structure, and Conformation in Solution

Author

Klaus Gerth, Norbert Bedorf, Hans Reichenbach, Dietmar Schomburg, Gerhard Hoefle, and Heinrich Steinmetz

Subjects
Bacterial gliding, medicine.drug_class, Stereochemistry, Chemistry, Antibiotics, medicine, Cytotoxic T cell, General Medicine, Crystal structure, Epothilone A, Isolation (microbiology), Combinatorial chemistry
Published
2010
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8. ChemInform Abstract: Carolacton - A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated Bacterium Streptococcus mutans

Author

Volker Huch, Martin Bock, Andreas Kirschning, Rolf Mueller, Thomas J. Schmidt, Rolf Jansen, Dietmar Schummer, Heinrich Steinmetz, and Herbert Irschik

Subjects
biology, medicine.drug_class, Chemistry, Antibiotics, Biofilm, General Medicine, biology.organism_classification, medicine.disease, Streptococcus mutans, Microbiology, Carolacton, medicine, Endocarditis, Bacteria
Published
2010
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9. ChemInform Abstract: Antibiotics from Gliding Bacteria. Part 84. Melithiazols, New β-Methoxyacrylate Inhibitors of the Respiratory Chain Isolated from Myxobacteria. Production, Isolation, Physico-chemical, and Biological Properties

Author

Edgar Forche, Gerhard Hoefle, Bettina Boehlendorf, Hans Reichenbach, Brigitte Kunze, Martina Hermann, Florenz Sasse, and Heinrich Steinmetz

Subjects
Bacterial gliding, biology, Chemistry, medicine.drug_class, Antibiotics, Respiratory chain, General Medicine, Isolation (microbiology), biology.organism_classification, Combinatorial chemistry, Myxobacteria, Biochemistry, Biological property, medicine
Published
2010
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13. Archazolid-7-O-β-D-glucopyranoside — Isolation, Structural Elucidation and Solution Conformation of a Novel V-ATPase Inhibitor from the Myxobacterium Cystobacter violaceus

Author

Heinrich Steinmetz, Dirk Menche, Jorma Hassfeld, Florenz Sasse, Helmut Wieczorek, and Markus Huss

Subjects
Polyketide, Stereochemistry, Chemistry, Regioselectivity, V-ATPase, General Medicine, Cystobacter violaceus
Abstract

The novel polyketide macrolide archazolid-7-O-β-D-glucopyranoside (3) has been isolated from the myxobacterium Cystobacter violaceus and the structure of this first archazolid-glycoside has been determined by spectroscopic and degradative methods. A synthesis of simplified 7-O analogues, based on regioselective derivatisation of archazolid A, was elaborated. These structurally novel archazolids of natural and synthetic origin were evaluated in detail for V-ATPase inhibition and their biological activities are discussed in terms of their solution conformations, as determined by high-field NMR studies, including J-based conformation analysis and constrained molecular dynamics simulations. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

Published
2007
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14. Cruentaren, a New Antifungal Salicylate-Type Macrolide from Byssovorax cruenta (Myxobacteria) with Inhibitory Effect on Mitochondrial ATPase Activity. Fermentation and Biological Properties. Part 104. Antibiotics from Gliding Bacteria

Author

Hans Reichenbach, Helmut Wieczorek, Gerhard Hoefle, Markus Huss, Heinrich Steinmetz, and Brigitte Kunze

Subjects
Bacterial gliding, Mitochondrial ATPase activity, biology, medicine.drug_class, Antibiotics, General Medicine, biology.organism_classification, chemistry.chemical_compound, Myxobacteria, Biochemistry, chemistry, Biological property, Cruentaren, medicine, Fermentation, Inhibitory effect
Published
2007
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15. Antibiotics from GIiding Bacteria. Part 105. Isolation and Structure Elucidation of Cruentarens A and B — Novel Members of the Benzolactone Class of ATPase Inhibitors from the Myxobacterium Byssovorax cruenta

Author

Hans Reichenbach, Larissa Jundt, Gerhard Hoefle, Manuela Weber, Heinrich Steinmetz, Peter Luger, and Brigitte Kunze

Subjects
Byssovorax cruenta, biology, Stereochemistry, Chemistry, medicine.drug_class, ATPase, Antibiotics, General Medicine, Isolation (microbiology), biology.organism_classification, Biochemistry, biology.protein, medicine, Bacteria
Published
2007
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17. Antibiotics from Gliding Bacteria. Part 103. Spirangien A and B, Highly Cytotoxic and Antifungal Spiroketals from the Myxobacterium Sorangium cellulosum: Isolation, Structure Elucidation and Chemical Modifications

Author

Jutta Niggemann, Heinrich Steinmetz, Hans Reichenbach, Ulrich Floerke, Gerhard Hoefle, Klaus Gerth, and Norbert Bedorf

Subjects
Antifungal, Bacterial gliding, biology, medicine.drug_class, Chemistry, Stereochemistry, Antibiotics, medicine, Cytotoxic T cell, General Medicine, biology.organism_classification, Isolation (microbiology), Sorangium cellulosum
Published
2006
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18. Isolation, Crystal and Solution Structure Determination, and Biosynthesis of Tubulysins ? Powerful Inhibitors of Tubulin Polymerization from Myxobacteria

Author

Eberhardt Herdtweck, Hans Reichenbach, Gerhard Hoefle, Nicole Glaser, Florenz Sasse, and Heinrich Steinmetz

Subjects
Crystal, chemistry.chemical_compound, Biosynthesis, chemistry, Myxobacteria, biology, Tubulin polymerization, General Medicine, Isolation (microbiology), biology.organism_classification, Combinatorial chemistry, Solution structure
Published
2005
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19. Archazolids, New Cytotoxic Macrolactones from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties

Author

Gerhard Höfle, Hans Reichenbach, Florenz Sasse, and Heinrich Steinmetz

Subjects
Male, Stereochemistry, Microbial Sensitivity Tests, chemistry.chemical_compound, Lactones, Mice, Myxobacteria, Biological property, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Thiazole, Pharmacology, chemistry.chemical_classification, Archangium gephyra, Antibiotics, Antineoplastic, biology, Chemistry, Bafilomycin, Biological activity, General Medicine, Fibroblasts, Isolation (microbiology), biology.organism_classification, In vitro, Biochemistry, Cell culture, Fermentation, Female, Bacteria, Lactone
Abstract

Novel cytotoxic compounds, archazolid A and B, were isolated from the culture broth of strains of the myxobacteria Archangium gephyra and Cystobacter sp. Archazolids consist of a macrocyclic lactone ring with a thiazole side chain and showed high activity against mammalian cells. The IC50 values with different cell lines ranged from 0.1 to 1 ng/ml. An incubation of PtK2 potoroo cells with archazolid A (5 ng/ml) led to the formation of vacuoles in the ER, a phenomenon that is typical for inhibitors of V-ATPases, like concanamycin and bafilomycin. We therefore assume that archazolid is an inhibitor of the V-ATPase of higher cells.

Published
2003
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