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A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines has been successfully developed, providing direct and facile access to chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethylthio group with up to 99% enantioselectivity.

A new visible-light catalysis strategy for the synthesis of functionalized oxindoles by reaction of various N-arylacrylamides with acetonitrile or acetone.

A facile conversion of 3-tosylmethyl functionalized N-unsubstituted indoles to spirocyclic dearomatized products is developed using sulfonium salts as reagents under mild basic conditions.

Bovine pancreatic lipase is used for the aldol reactions of cyclic ketones with aromatic aldehydes.

A novel method for the generation of o-quinone methide intermediates from 2-tosylalkylphenols (I) is reported.

A variety of aryl- and alkyl-substituted sulfonylindoles smoothly undergoes Rh-catalyzed arylation reaction to give indole derivatives (III), (V), (VII) in moderate to excellent yields.

A simple procedure is developed for the reaction of indoles with aldehydes or ketones to yield 3-substituted derivatives.

Highly enantioselective dehydration—hydrogenation of title α-hydroxyalkylindoles is smoothly achieved under Pd-catalysis in the presence of Bronsted acid promotor to give the corresponding 3-alkylindolines (II) and (IV) in high to excellent yields and enantioselectivities (up to 97% e.e.).

Synthesis and reactivity of perfluoroalkylated diethoxyphosphinyl triphenylphosphoranes is described. The crystal structure of [(1-diethoxyphosphinyl)-(2-dimethylmethylidene)-3,3,4,4,4-pentafluorobutylidene] triphenylphosphorane has been determined and the bond P-(ylide) order is 1.84 which accounts for its lower reactivity with benzaldehyde than diethoxyphosphinylmethylidene triphenylphosphorane.

The 2,2-difluoro-1-tosyloxyvinyl anion 2 , generated from the 2,2,2-trifluoroethyl p -toluenesulfonate 1 and 2 eq of n -butyllithium, reacted with α-ethoxycarbonyl vinylphosphonate 3 to give the phosphoryl-stabilized carbanion 4 which reacted further with a variety of aldehydes affording functionalized gem -difluoro-penta-1,4-dienes in 69–96% yields.

A convenient method for the synthesis of perfluoroalkylated indolizinyl-phosphonates via the 1,3-cycloaddition of pyridinium N-ylide and perfluoroalkynyl phosphonate in 49 77% yields is described.

‘Regiocontrolled syntheses of 3-methoxycarbonyl-1,3-dienylphosphonates and 1-[(3-methoxycarbonyl)-allyl]vinylphosphonates by using different conditions are described. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:373–376, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10050

Regiocontrollable selectivity of enzymatic method for synthesis of polymerizable derivatives of methyl shikimate was described. Lipase acrylic resin from Candida antarctica (CAL-B) and immobilized lipase from Mucor miehei (MML) showed high regioselectivity toward the secondary hydroxyl of methyl shikimate, which presents three hydroxyl groups with similar reactivity. Catalysis by MML in acetone facilitated the single step synthesis of 5-O-acyl methyl shikimate derivatives in high yields, while the use of CAL-B in acetone afforded 4-O-acyl methyl shikimate derivatives. The obtained series of methyl shikimate derivatives would be important monomers for potential useful analogues of shikimic acid.