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2. ChemInform Abstract: Expanding Dialogues: From Natural Autoinducers to Non-Natural Analogues that Modulate Quorum Sensing in Gram-Negative Bacteria

Author

Helen E. Blackwell, Jennifer C. O'Neill, and Grant D. Geske

Subjects
Quorum sensing, Gram-negative bacteria, biology, Chemistry, food and beverages, Autoinducer, Local population, General Medicine, Computational biology, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Bacteria
Abstract

Bacteria are capable of “communicating” their local population densities via a process termed quorum sensing (QS). Gram-negative bacteria use N-acylated L-homoserine lactones (AHLs), in conjunction with their cognate LuxR-type receptors, as their primary signalling circuit for QS. In this critical review, we examine AHL signalling in Gram-negative bacteria with a primary focus on the design of non-natural AHLs, their structure-activity relationships, and their application in chemical biological approaches to study QS (72 references).

Published
2008
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