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Conversion of nitriles under mild conditions leads to a new class of primary amines, including room temperature ionic liquids, acting as efficient anticancer agents.

The reactions with 2-chloroacetoacetate (II), 3-chloroacetylacetone (IV) and dimethylchloromalonate (VI) proceed with good to excellent dia- and high enantioselectivities.

The current review represents a systematic survey of the use of 2- and 3-carenes in the synthesis of chiral non-racemic organic compounds containing a 2,2-dimethyl-1,3-disubstituted cyclopropane fragment. The synthetic approaches to the cyclopropane derivatives are classified on the basis of the retention of their parent carane bicyclic skeleton in the final product or cleavage of the six-membered ring along the synthetic route.