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36 results on '"Deng, Yuan"'

1. ChemInform Abstract: Palladium-Catalyzed Tandem Reaction of Alkyne-Based Aryl Iodides and Salicyl N-Tosylhydrazones to Construct the Spiro[benzofuran-3,2′-chromene] Skeleton

Author

Xue Song Shang, Nian Tai Li, Deng Yuan Li, and Pei Nian Liu

Subjects
chemistry.chemical_classification, Aryl, Migratory insertion, chemistry.chemical_element, Alkyne, General Medicine, Medicinal chemistry, Catalysis, chemistry.chemical_compound, chemistry, Cascade reaction, Benzofuran, Carbene, Palladium
Abstract

A convenient palladium-catalyzed tandem reaction of aryl iodides and salicyl N-tosylhydrazones has been achieved to afford a series of compounds containing the novel spiro[benzofuran-3,2′-chromene] scaffold in moderate to good yields. This efficient catalytic reaction, which tolerates various functional groups, combines alkyne-based 5-exo-dig cyclization, palladium(II) carbene migratory insertion and intramolecular cyclization, generating three new bonds in one reaction.

Published
2016
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2. ChemInform Abstract: Tunable Cascade Reactions of Alkynols with Alkynes under Combined Sc(OTf)3and Rhodium Catalysis

Author

Deng Yuan Li, Pei Nian Liu, and Hao Jie Chen

Subjects
chemistry.chemical_classification, Reaction conditions, Cascade reaction, chemistry, Cascade, chemistry.chemical_element, Alkyne, General Medicine, Combinatorial chemistry, Bond cleavage, Rhodium, Catalysis
Abstract

Two tunable cascade reactions of alkynols and alkynes have been developed by combining Sc(OTf)3 and rhodium catalysis. In the absence of H2O, an endo-cycloisomerization/C-H activation cascade reaction provided 2,3-dihydronaphtho[1,2-b]furans in good to high yields. In the presence of H2O, the product of alkynol hydration underwent an addition/C-H activation cascade reaction with an alkyne, which led to the formation of 4,5-dihydro-3H-spiro[furan-2,1'-isochromene] derivatives in good yields under mild reaction conditions. Mechanistic studies of the cascade reactions indicated that the rate-determining step involves C-H bond cleavage and that the hydration of the alkynol plays a key role in switching between the two reaction pathways.

Published
2016
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3. ChemInform Abstract: Ruthenium Complex-Catalyzed Domino Addition/exo-Cycloisomerization of Propargylic Alcohols and Tosyl Isocyanate to Form Oxazolidinones

Author

Pei Nian Liu, Deng Yuan Li, and Hao Jie Chen

Subjects
inorganic chemicals, Ligand, fungi, chemistry.chemical_element, macromolecular substances, General Medicine, Isocyanate, Medicinal chemistry, Domino, Ruthenium, Catalysis, carbohydrates (lipids), chemistry.chemical_compound, Cycloisomerization, Tosyl, chemistry, otorhinolaryngologic diseases
Abstract

A tetradentate nitrogen-phosphorus ligand is used for the ruthenium-catalyzed title reaction with high exo-selectivity.

Published
2015
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4. ChemInform Abstract: Selective Cyclization of Alkynols and Alkynylamines Catalyzed by Potassium tert-Butoxide

Author

Zheng Le Zhao, Deng Yuan Li, Pei Nian Liu, Xin Yan Wu, Xiao Feng Mao, and Ke Ji Shi

Subjects
chemistry.chemical_compound, chemistry, Potassium, Organocatalysis, Potassium tert-butoxide, chemistry.chemical_element, Organic chemistry, General Medicine, Selectivity, Enol, Catalysis
Abstract

Potassium tert -butoxide ( t -BuOK) was found to be an effective catalyst for the cyclization of aromatic alkynols and alkynylamines. In the presence of 10 mol % t -BuOK, a range of alkynols were converted to the corresponding exo -cyclic enol ethers as pure Z -stereoisomers with 100% selectivity and moderate to excellent yields. Moreover, the cyclization of alkynylamines was also achieved to afford indoles and isoindolin-1-ones in good yields.

Published
2015
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5. ChemInform Abstract: Transition Metal-Free Cascade Reactions of Alkynols to Afford Isoquinolin-1(2H)-one and Dihydroisobenzofuran Derivatives

Author

Deng Yuan Li, Guo Rong Chen, Ke Ji Shi, Xiao Feng Mao, and Pei Nian Liu

Subjects
Solvent, Cascade reaction, Transition metal, Chemistry, Computational chemistry, Cascade, Organic chemistry, General Medicine
Abstract

The result of the title cascade reaction of alkynols with imines depends on the solvent used (DMSO or THF).

Published
2014
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6. ChemInform Abstract: Solvent-Switched Benzylic Methylene Functionalization: Addition, Ring-Opening, Cyclization, and Unexpected Cleavage of C-O and C-C Bonds

Author

Guo Rong Chen, Xue Song Shang, Pei Nian Liu, and Deng Yuan Li

Subjects
Solvent, Elimination reaction, chemistry.chemical_compound, Cascade reaction, Chemistry, Yield (chemistry), General Medicine, Methylene, Ring (chemistry), Photochemistry, Enol, Medicinal chemistry, Catalysis
Abstract

Intermolecular benzylic methylene functionalization of exo-cyclic enol ethers has been achieved using imines as reagents and potassium tert-butoxide as the catalyst. Depending on the solvent used, the reaction proceeds by two pathways. In THF, an addition/elimination reaction of exo-cyclic enol ethers with imines provides dihydroisobenzofuran derivatives in good yield. In DMSO, an addition/ring-opening/cyclization cascade reaction occurs with unexpected cleavage of C–O and C–C bonds, affording isoquinolin-1(2H)-one products in high yield under ambient reaction conditions.

Published
2013
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35. Rhodium-Catalyzed Addition--Cyclization of Hydrazines with Alkynes: Pyrazole Synthesis via Unexpected C--N Bond Cleavage.

Author

Li, Deng Yuan, Mao, Xiao Feng, Chen, Hao Jie, Chen, Guo Rong, and Liu, Pei Nian

Subjects
*RHODIUM catalysts, *RING formation (Chemistry), *HYDRAZINES
Abstract

This reaction provides a highly concise and effective protocol to prepare substituted pyrazoles. The formal [3 + 2] cycloaddition involves the addition of a C--N bond to alkyne, subsequent cleavage of the C--N bond, and finally cyclization. [ABSTRACT FROM AUTHOR]

Published
2015
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