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9 results on '"Dave G"'

1. ChemInform Abstract: Palladium-Catalyzed Cross-Coupling Reactions of Potassium N-Methyltrifluoroborate Isoindolin-1-one with Aryl and Heteroaryl Chlorides

Author

Dave G. Seapy and Rashid N. Nadaf

Subjects
Reaction conditions, chemistry.chemical_compound, Chemistry, Potassium, Aryl, chemistry.chemical_element, Isoindolin 1 one, General Medicine, Boron, Medicinal chemistry, Coupling reaction, Palladium, Catalysis
Abstract

The title borate (III) undergoes Pd-catalyzed Suzuki—Miyaura cross-coupling with aryl and heteroaryl chlorides leading to N-benzylisoindolin-1-ones under mild reaction conditions.

Published
2014

2. ChemInform Abstract: Suzuki-Miyaura Cross-Coupling of Potassium Trifluoro(N-methylheteroaryl)borates with Aryl and Heteroaryl Halides

Author

Mona Hosseini-Sarvari, Rammohan Devulapally, DaWeon Ryu, Dave G. Seapy, and Gary A. Molander

Subjects
Coupling (electronics), chemistry.chemical_compound, Chemistry, Aryl, Potassium, Halide, chemistry.chemical_element, General Medicine, Boron, Medicinal chemistry, Pyrrole derivatives
Abstract

The synthesis of potassium trifluoro(N-methylheteroaryl)borates and their use in cross-coupling reactions with various aryl and heteroaryl halides to construct N-methyl heteroaryl-substituted aromatic and heteroaromatic compounds are reported.

Published
2013

3. ChemInform Abstract: Synthesis and Cross-Coupling Reactions of Imidomethyltrifluoroborates with Aryl Chlorides

Author

Gary A. Molander, Rammohan Devulapally, Dave G. Seapy, and Nicolas Fleury-Brégeot

Subjects
chemistry.chemical_compound, Chemistry, Aryl, General Medicine, Combinatorial chemistry, Coupling reaction
Abstract

The reaction is conveniently achieved by Suzuki—Miyaura-like cross-coupling with trifluoroborate (III), which is easily prepared by an optimized procedure.

Published
2012

4. ChemInform Abstract: Conformationally Restricted Indolopiperidine Derivatives as Potent CCR2B Receptor Antagonists

Author

Jayneeta Gohil, Pieter H.E. Groot, Robert J. Ife, Theo A. Berkhout, Jason Witherington, Dave G. Cooper, Ian Thomson Forbes, Vincent Bordas, and Andrew D. Gribble

Subjects
chemistry.chemical_compound, Stereochemistry, Chemistry, Dopamine receptor, Indolopiperidine, General Medicine, Piperidine, Selectivity, Ring (chemistry), Receptor, Linker, Biological evaluation
Abstract

The preparation and biological evaluation of a series of indolopiperidine CCR2B receptor antagonists possessing a conformationally restricted C-5 linker chain in combination with a restricted piperidine ring are described. Compared to the parent compound 1, analogue 8 shows a dramatic improvement in selectivity against a range of 5-HT and dopaminergic receptors.

Published
2010

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