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167 results on '"Chang-An Wei"'

4. ChemInform Abstract: New Ring Construction Strategy in Taxane Synthesis: Stereocontrolled Synthesis of Taxane CB-Ring System

Author

Gang Zhao, Xiang-Rong Jiang, Chang-Qing Wei, and Yu Ding

Subjects
Taxane, Aldol reaction, Chemistry, Stereochemistry, Intramolecular force, Intermolecular force, Aldol condensation, General Medicine, Ring (chemistry)
Abstract

A concise stereocontrolled construction of taxane CB-ring system (C→CB) is described. The key bottom and top linking of the eight-membered B-ring were realized unprecedentedly by way of successive intermolecular aldol condensation and intramolecular aldol cyclization.

Published
2010

5. ChemInform Abstract: Olefin Metathesis in the Design and Synthesis of a Globally Constrained Grb2 SH2 Domain Inhibitor

Author

Chang-Qing Wei, Terrence R. Burke, and Yang Gao

Subjects
Olefin fiber, Olefin metathesis, biology, Chemistry, Salt metathesis reaction, Side chain, biology.protein, General Medicine, GRB2, Ring (chemistry), SH2 domain, Combinatorial chemistry
Abstract

One drawback frequently associated with olefin metathesis-mediated peptide macrocyclization, the loss of side chain functionality at sites of ring closure, may be circumvented by incorporation of side chain functionality within the ring-closing olefin segments. This approach is demonstrated in the preparation of a macrocyclic Grb2 SH2 domain antagonist designed as a conformationally constrained β-bend mimic.

Published
2010

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