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Your search keyword '"C. Lovelace"' showing total 5 results
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5 results on '"C. Lovelace"'

1. ChemInform Abstract: Enzymes and Practical Asymmetric Synthesis

Author

James M. McNamara, Paul J. Reider, David L. Hughes, Robert A. Reamer, Edward J. J. Grabowski, J. L. Leazer, Ichiro Shinkai, J. J. Bergan, T. C. Lovelace, J. S. Amato, M. Bhupathy, and Daniel R. Sidler

Subjects
chemistry.chemical_classification, Enzyme, Chemistry, Yield (chemistry), Enzymatic hydrolysis, Enantioselective synthesis, Antagonist, Organic chemistry, General Medicine, Enantiomeric excess
Abstract

A practical, chemoenzymatic, four-step synthesis of the LTD4 antagonist MK-0679 is described. The key steps are enzymatic hydrolysis of the prochiral diester to the ester-acid in 99% enantiomeric excess followed by aluminum mediated amidation of the methyl ester to afford MK-0679 in high overall yield. This synthesis is superior to the synthesis of the racemate MK-0571.

Published
2010
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2. ChemInform Abstract: Aluminum-Amine Complexes for the Conversion of Carboxylic Esters to Amides. Application to the Synthesis of LTD4 Antagonist MK-0679

Author

James M. McNamara, T. C. Lovelace, Paul J. Reider, and Daniel R. Sidler

Subjects
chemistry, Aluminium, Antagonist, medicine, chemistry.chemical_element, Amine gas treating, General Medicine, Medicinal chemistry, Chloride, medicine.drug
Abstract

The preparation and characterization of N,N-dimethylammonium dialkylaluminum chloride and the use of these complexes in the synthesis of the LTD 4 antagonist MK-0679 is described

Published
2010
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4. ChemInform Abstract: Intramolecular (4 + 1)Pyrroline Annulation via Azide-Diene Cycloadditions. Part 2. Formal Stereoselective Total Syntheses of (.+-.)-Platynecine, (.+-.)-Hastanecine, (.+-.)-Turneforcidine, and (.+-.)-Dihydroxyheliotridane

Author

G. Seoane, T. C. Lovelace, and Tomas Hudlicky

Subjects
chemistry.chemical_compound, Annulation, Hastanecine, chemistry, Diene, Stereochemistry, Platynecine, Intramolecular force, Stereoselectivity, General Medicine, Azide, Pyrroline
Published
1988
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5. ChemInform Abstract: (2+3) Dihydrofuran Annulation via Vinyloxiranation of Carbonyl Compounds

Author

T. C. Lovelace, A. Fleming, and Tomas Hudlicky

Subjects
chemistry.chemical_compound, Annulation, chemistry, chemistry.chemical_element, Cyclopentene, Stereoselectivity, Lithium, General Medicine, 2,3-Dihydrofuran, Medicinal chemistry
Abstract

Aldehydes were found to undergo facile stereoselective vinyloxiranation with the lithium dienolate of ethyl 2-bromocrotonate (12) at low temperature. The resulting vinyloxiranes were transformed thermolytically to functionalized dihydrofurans. An operational comparison of this heterocyclic annulation is made with its carbocyclic counterpart, the [2+3] cyclopentene annulation, and the potential for a general dihydrofuran synthesis in either a racemic or an asymmetric fashion is addressed.

Published
1989
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