Search

The high yielding reaction between benzimidazole hydrazides and (benzotriazolylcarbonyl)chromenone is performed in a very small amount of solvent without a catalyst.

Some of the title compounds (III) show significant anticonvulsant activity in MES-induced seizure test.

A simple and green protocol has been developed for the synthesis of benzimidazoles. In this protocol, 2-[(alkyl/aryl)(ethoxy)methylidene]hydrazinecarboxylates with 1,2-phenylenediamine derivatives under solvent- and catalyst-free conditions under microwave irradiation lead to products with good yields in short reaction times.

A series of title compounds are prepared and screened for their lipase inhibition and antioxidant activities.

Title compounds [(III), (V), and (VI)] are efficiently synthesized and shown to have anti-lipase, antiviral, and antitumor activities.

Several title compounds of type (III), (V), and (VII) are prepared under microwaves irradiation.

An efficient and easy method for the synthesis of triazolone derivatives (III) and their conversion into 5-mercapto-1,3,4-oxadiazole derivatives (VIII) using microwave chemistry is described.

Some new N-alkoxycarbonyl-N′′-benzoyl-benzamidrazones (p-toluamidrazones) 3a–3d, and 1,3,5-trisubstituted 1,2,4-triazole 4a–4h derivatives by starting from N-benzoylbenzimidates or N-benzoyl-p-toluimidates. The structures of compounds 3 and 4 were established on the basis of elemental analyses, IR, 1H NMR, 13C NMR and UV data. Antimicrobial experiments of the compounds performed by using agar-well diffusion and broth microdilution methods revealed that only compounds 3a–3d, 4a and 4b showed inhibitory effect only on Candida albicans ATCC 60193. However, compound 4b had also specific antibacterial activity against Staphylococcus aureus ATCC 25923. The other compounds showed neither antifungal nor antibacterial activities. Compounds 3a, 4a and 4b have been screened on three human tumor cell lines, breast cancer (MCF7), non small cell lung cancer (NCI-H460), and CNS cancer (SF-268) at the National Cancer Institute (NCI), USA, which were found to exhibit low antiproliferative activity.

WOS: 000234124500020 Eight new ethyl N'-(3-methyl-4-arylmethyleneamino-4,5-dihydro-1H-1,2,4-triazolyl-5-one)acetates 2 and N'-(3-methyl-4-arylmethyleneamino-4,5-dihydro-1H-1,2,4-triazolyl-5-one)acetyl-hydrazines 3 have been synthesized. The structures of the compounds have been confirmed by IR and H-1 NMR spectra and microanalysis. The compounds show some antimicrobial activities. Compound 2a shows antibacterial activity against B. subtilis. Compounds 3a, 3b and 3d have antifungal activity against Candida species.

WOS: 000188840500006 A series of 3-arylidenamino-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-ones N were obtained from the reaction of 3-amino-4-phenyl-45-dihydro-1H-1,2,4-triazol-5-one IVa with certain aldehydes. Compounds V were hydrogenated with NaBH, in diglyme to afford 3-alkylamino-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-ones. VI. So, a general and convenient method was improved for the synthesis of type VI compounds. Eleven new and potential biologically active compounds were synthesized and characterized by elemental analyses, C-13-NMR, H-1-NMR, UV and IR spectra.

A series of 3-alkyl-4-(arylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 are obtained and reduced with NaBH 4 selectively to afford 3-alkyl-4-(arylmethylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3. Compounds of type 2 have recently described as a new class of antitumor agent. Thus, 15 new compounds have been synthesized and characterized by elemental analyses, 1 H NMR, IR and UV spectra. Three of these compounds have been screened for their antitumor activities and found weak cytostatic activity in them.