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Your search keyword '"Atsushi Nagasawa"' showing total 4 results
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4 results on '"Atsushi Nagasawa"'

3. ChemInform Abstract: Double Stereocontrol in α-Alkylation of Chiral Lithium Dienolates Generated from (E)-α,β-Olefinic Amides and Esters

Author

Katsuhiko Tomooka, Atsushi Nagasawa, and Takeshi Nakai

Subjects
chemistry.chemical_compound, Chiral auxiliary, chemistry, Stereochemistry, Amide, chemistry.chemical_element, Lithium, General Medicine, Olefinic bond, Alkylation
Abstract

The methylation of the lithium dienolate generated from (E)-α,β-olefinic amide with Katsuki’s chiral auxiliary affords the α-methylated β,γ-enamide in an exceptionally high Z-selectivity (99%) over the terminal olefinic bond along with 99% de at the α-chiral center. The origin of the high Z-selectivity is discussed.

Published
2010

4. Asymmetric Opening of the Epoxide Ring in Cyclohexene Oxide by Thiophenol Using Homochiral Phosphinamide Catalysts

Author

Changxue Lin, Martin Wills, and Atsushi Nagasawa

Subjects
chemistry.chemical_compound, chemistry, Group (periodic table), Thiophenol, Organic chemistry, Epoxide, General Medicine, Ring (chemistry), Enantiomeric excess, Medicinal chemistry, Catalysis, Cyclohexene oxide
Abstract

Enantiomerically pure phosphinamides containing a pendant hydroxyl group catalyse the Al(III)-promoted ring opening of the meso epoxide in cyclohexene oxide with thiophenol in up to 80% enantiomeric excess.

Published
2007

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