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Your search keyword '"Archangium gephyra"' showing total 3 results
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3 results on '"Archangium gephyra"'

1. ChemInform Abstract: Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis. Part 1. Structural Revision and Stereochemical Assignment of Gephyronic Acid

Author

Sabine Laschat, Richard E. Taylor, R. Jansen, Heinrich Steinmetz, Timo Anderl, Lionel Nicolas, Gerhard Hoefle, and Florenz Sasse

Subjects
Archangium gephyra, Polyketide, Chemistry, Stereochemistry, Protein biosynthesis, General Medicine, Link (geometry), Gephyronic acid
Abstract

The structure of the title compound, a constituent of the myxobacterium Archangium gephyra (Ar 3895) which exists as a separable mixture of keto and hemiketal isomers, is unambiguously confirmed as (I).

Published
2011

3. Archazolids, New Cytotoxic Macrolactones from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties

Author

Gerhard Höfle, Hans Reichenbach, Florenz Sasse, and Heinrich Steinmetz

Subjects
Male, Stereochemistry, Microbial Sensitivity Tests, chemistry.chemical_compound, Lactones, Mice, Myxobacteria, Biological property, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Thiazole, Pharmacology, chemistry.chemical_classification, Archangium gephyra, Antibiotics, Antineoplastic, biology, Chemistry, Bafilomycin, Biological activity, General Medicine, Fibroblasts, Isolation (microbiology), biology.organism_classification, In vitro, Biochemistry, Cell culture, Fermentation, Female, Bacteria, Lactone
Abstract

Novel cytotoxic compounds, archazolid A and B, were isolated from the culture broth of strains of the myxobacteria Archangium gephyra and Cystobacter sp. Archazolids consist of a macrocyclic lactone ring with a thiazole side chain and showed high activity against mammalian cells. The IC50 values with different cell lines ranged from 0.1 to 1 ng/ml. An incubation of PtK2 potoroo cells with archazolid A (5 ng/ml) led to the formation of vacuoles in the ER, a phenomenon that is typical for inhibitors of V-ATPases, like concanamycin and bafilomycin. We therefore assume that archazolid is an inhibitor of the V-ATPase of higher cells.

Published
2003

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