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5 results on '"Ales Machara"'

1. ChemInform Abstract: A Modular Synthesis of N-Benzotriazole Ureas Using Alkylation of 5-Nitrobenzotriazole

Author

Martin Kotora, Jan Konvalinka, and Ales Machara

Subjects
chemistry.chemical_compound, Benzotriazole, Chemistry, Triazole derivatives, Nitro, General Medicine, Urea derivatives, Alkylation, Combinatorial chemistry
Abstract

Various alkyl-amino-benzotriazoles obtained by reduction of the corresponding nitro compounds are used as starting materials for the synthesis of urea derivatives.

Published
2016
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3. ChemInform Abstract: Synthesis of Nalbuphine from Oripavine via N-Demethylation of N-Cyclobutylmethyl Oripavine

Author

D. Phillip Cox, Tomas Hudlicky, and Ales Machara

Subjects
Oripavine, Chemistry, Stereochemistry, medicine, General Medicine, Nalbuphine, medicine.drug, Demethylation
Abstract

The synthesis of nalbuphine (VI) from oripavine (I) requires only five chemical transformations and is conducted with an overall yield of 45%, in contrast to current methods requiring seven to ten steps.

Published
2012
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5. Synthesis and Cycloaddition Reaction of 3-Vinylthieno[3,2-b][1]benzothiophene

Author

Ales Machara, Jiri Svoboda, and Michaela Pojarová

Subjects
Dimethyl acetylenedicarboxylate, Pericyclic reaction, Chemistry, Benzothiophene, General Chemistry, General Medicine, Medicinal chemistry, Cycloaddition, Adduct, chemistry.chemical_compound, Halogen, Organic chemistry, Ene reaction, Diels–Alder reaction
Abstract

A new method of synthesis of 3-substituted thieno[3,2-b][1]benzothiophenes based on a halogen dance process was developed. The cycloaddition reaction of the title compound with dimethyl acetylenedicarboxylate leads to the formation of a complex mixture of products resulting from a series of consecutive reactions of the primary adduct.

Published
2007
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