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9 results on '"Yoshihiro Nitta"'

1. Reaction of amino acids with alkyl p-toluenesulfonates

Author

Yoshihiro Nitta and Yasushi Arakawa

Subjects
chemistry.chemical_classification, Ethanol, Chemical Phenomena, Carboxylic acid, Benzenesulfonates, Alcohol, General Chemistry, General Medicine, Catalysis, Amino acid, chemistry.chemical_compound, Acid catalysis, Chemistry, Sulfonate, chemistry, Drug Discovery, Organic chemistry, Beta-Hydride elimination, Amino Acids, Alkyl
Abstract

Recently, it has been reported that the treatment of amino acids with alkyl p-toluenesulfonates in alcohol affords the p-toluenesulfonates of the corresponding alkyl esters in high yields. The results of our examination of this reaction indicated that the reaction proceeds predominantly through the general acid-catalyzed esterification of carboxylic acid by alcohol, and the involvement of transesterification is minor.

Published
1985

2. Pyrimidine derivatives. I. Synthesis of a new series of sulfanilamides having dialkylamino groups in the pyrimidine nucleus

Author

Yoshihiro Nitta, Kiyoshi Okui, and Kiyohiko Ito

Subjects
Sulfonamides, Pyrimidine, Stereochemistry, Chemistry, Pharmaceutical, General Chemistry, General Medicine, Sulfanilamide, chemistry.chemical_compound, medicine.anatomical_structure, Pyrimidines, chemistry, Drug Discovery, medicine, Nucleus, medicine.drug
Abstract

The synthesis of a number of sulfonamides having dialkylamino groups in the pyrimidine nucleus was described. Among these new compounds, N1-(6-chloro-2-dialkylamino-4-pyrimidyl)sulfanilamide were found to possess notable antibacterial activities.

Published
1965

3. PYRIDAZINE DERIVATIVES. IV. THE STRUCTURES OF AMINOPYRIDAZINES

Author

Fumio Yoneda, Yoshihiro Nitta, and Reiko Tomii

Subjects
Structural similarity, Chemistry, Pharmaceutical, Research, Spectrum Analysis, Substituent, Infrared spectroscopy, General Chemistry, General Medicine, Photochemistry, Spectral line, Pyridazine, Pyridazines, chemistry.chemical_compound, Crystallography, Aniline, chemistry, Drug Discovery, Spectrum analysis, Aminopyridines
Abstract

The infrared absorption spectra of the two aminopyridazines were observed and compared with those of the three aminopyridines and aniline. The amino-form of the two aminopyridazines was confirmed, and at the same time the structural similarity of 4-aminopyridazine with 4-aminopyridine was shown by their infrared spectra. Similarly, the spectrum of 3-aminopyridazine was close to that of 2-aminopyridine. In addition, the correlation between the position and the nature of substituent was discussed.

Published
1963

5. Electronic structure and local anesthetic activity of 2-diethylaminoacetanilide derivatives

Author

Fumio Yoneda and Yoshihiro Nitta

Subjects
Local anesthetic, medicine.drug_class, Stereochemistry, Chemistry, Chemistry, Pharmaceutical, education, General Chemistry, General Medicine, Electronic structure, Charge-transfer complex, Computational chemistry, Drug Discovery, medicine, Thiamine, Molecular orbital, Acetanilides, Anesthetics, Local
Abstract

The relation between the electronic structure and the local anesthetic activity of 2-diethylaminoacetanilide derivatives was investigated by a molecular orbital method and it was found that the stabilization energy due to the charge transfer complex formation between these compounds and thiamine has something to do with their local anesthetic activities.

Published
1965

6. Studies on analgesics of aniline series. II. Preparation and properties of N-alkyl or N,N-dialkyl 3-(N'-acyl-or N'-benzyl-substituted anilino)propionamide series and N-alkyl or N,N-dialkyl 3-(substituted anilino)propylamine series

Author

Tadahiro Yamamoto, Yoshihiro Nitta, Keiichi Takamura, Akihito Yoshimitsu, Katsumaro Minamoto, and Akitoshi Shioya

Subjects
chemistry.chemical_classification, Analgesics, Aniline Compounds, Propylamines, Chemistry, Formic acid, Chemistry, Pharmaceutical, Formaldehyde, Propylamine, General Chemistry, General Medicine, Medicinal chemistry, Amides, Acid anhydride, chemistry.chemical_compound, Mice, Benzyl chloride, Aniline, Drug Discovery, polycyclic compounds, Organic chemistry, Animals, lipids (amino acids, peptides, and proteins), Alkyl
Abstract

N-Alkyl or N, N-dialkyl 3-(N'-acyl-, N'-alkyl- or N'-benzylsubstituted anilino)propionamide derivatives were prepared from corresponding N-alkyl or N, N-dialkyl 3-(substituted anilino) propionamides by treating with acid anhydride, alkylhalide, or formaldehyde, formic acid and benzyl chloride, respectively. N, N-Dialkyl 3-(substituted anilino) propylamines were also prepared by condensation of 3-(substituted anilino) propyl chlorides with secondary amines. N, N-Dialkyl 3-(N'-acyl-substituted anilino) propylamines were obtained by treatment of 3-(substituted anilino) propylamines with acid anhydrides. Some of these compounds were found to possess analgetic activities.

Published
1965

9. D-Glucuronolactone derivatives. VII. Synthesis of anomeric 1-deoxy-1-halogeno-2,5-di-O-acyl-D-glucofuranurono-gamma-lactones

Author

Atsushi Momose, Yoshihiro Nitta, and Katsutoshi Kamei

Subjects
Anomer, Magnetic Resonance Spectroscopy, D-Glucuronolactone, Hydrogen bromide, Glucuronates, General Chemistry, General Medicine, Chloride, chemistry.chemical_compound, Lactones, Halogens, chemistry, Drug Discovery, medicine, Titanium tetrachloride, Organic chemistry, medicine.drug
Abstract

Treatment of 1-O-acety1-2, 5-di-O-benzoyl-and 5-O-benzoyl-1, 2-di-O-acety1-β-D-glucuronolactones with aluminum chloride or titanium tetrachloride afforded the corresponding anomeric 1-chloro-1-deoxy derivatives, respectively. 1-Bromo-1-deoxy-2-O-acetyl-5-O-benzol derivative was obtained from reaction of 1-O-acetyl-2, 5-di-O-benzoyl-β-D-glucuronolactone with hydrogen bromide. These compounds are very stable.

Published
1966

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