1. Cascade polycyclizations in natural product synthesis
- Author
-
R. Ardkhean, Yaoyao Xiong, Dimitri F. J. Caputo, Edward A. Anderson, S. M. Morrow, and H. Shi
- Subjects
Molecular complexity ,Pericyclic reaction ,Biological Products ,Natural product ,010405 organic chemistry ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Domino ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Cascade ,Cyclization - Abstract
Cascade (domino) reactions have an unparalleled ability to generate molecular complexity from relatively simple starting materials; these transformations are particularly appealing when multiple rings are forged during this process. In this tutorial review, we cover recent highlights in cascade polycyclizations as applied to natural product synthesis, including pericyclic, heteroatom-mediated, cationic, metal-catalyzed, organocatalytic, and radical sequences.
- Published
- 2016