1. Surfactant-facilitated crystallisation of water-soluble foldamers
- Author
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Gavin W. Collie, Karolina Pulka-Ziach, and Gilles Guichard
- Subjects
010405 organic chemistry ,Chemistry ,Foldamer ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,law.invention ,Water soluble ,Pulmonary surfactant ,law ,Crystallization - Abstract
Common surfactants promote the crystallisation of a series of water-soluble oligourea foldamers which had previously proven resistant to crystallisation efforts., X-ray crystallography has played a major role in the advancement of foldamer research, however, obtaining well-formed single crystals of suitable quality for structure determination by X-ray diffraction methods is often rather challenging. Towards this end, we report here the ability of common surfactants to promote the crystallisation of a series of water-soluble oligourea foldamers which had previously proven highly resistant to crystallisation. Four high-resolution crystal structures are reported, suggesting certain surfactants could be potentially useful tools for the crystallisation of intractable water-soluble foldamers (or peptides).
- Published
- 2016