1. Alpha-glucosidase inhibitors from Millettia conraui.
- Author
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Tiabou Tchinda A, Nahar Khan S, Fuendjiep V, Ngandeu F, Ngono Ngane A, and Choudhary MI
- Subjects
- 1-Deoxynojirimycin pharmacology, Magnetic Resonance Spectroscopy, Plant Bark chemistry, Plant Stems chemistry, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Enzyme Inhibitors isolation & purification, Enzyme Inhibitors pharmacology, Glycoside Hydrolase Inhibitors, Millettia chemistry
- Abstract
A new geranylated isoflavone, 7-O-geranyl-6-methoxypseudobaptigenin (1) was isolated from the stem barks of Millettia conraui, along with known compounds 5-methoxydurmillone (2), conrauinone A (3), beta-amyrine (4), sitosterol (5), 3-O-beta-D-glucopyranosyl sitosterol (6) and n-docosanol (7). Compounds 1 and 4 showed a significant alpha-glucosidase inhibitory activity. The structures of the compounds were determined by analysis of their spectroscopic data.
- Published
- 2007
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