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In the present study, monoethanolamine (MEA) was applied as a solvent for the extraction of polyphenols from lingonberry (Vaccinium vitis-idaea L.) pomace. In addition to solvent extraction an in situ DES could be formed with the secondary metabolites to obtain higher extraction yield. FT-IR, DSC, and TGA were used to validate MEA-based in situ DESs with reference compound. And the reusability of the solvent system still reached about 70.2% after the fifth cycles. The Box-Behnken experimental design method was used to determine the extraction efficiency under optimal conditions in practical applications, and the highest extraction yields of polyphenols increased 1.06–1.21 folds higher than that of traditional solvents. In addition, the extraction mechanism was studied using density functional theory. In summary, this study proposed a green and sustainable strategy to replace traditional solvents for targeted extraction of polyphenols from plants. [Display omitted] • Fully utilize polyphenol resources in by-products of Vaccinium vitis-idaea L. • Improve extraction efficiency by forming in-situ DESs with polyphenols in pomace. • The solvent can be recovered by bubbling CO 2 , and it can be used for 5 cycles. • The extraction method mentioned in this paper has never been reported. • Clarify the extraction mechanism by density functional theory. [ABSTRACT FROM AUTHOR]

A creative dual-template molecularly imprinted polymer (Fe 3 O 4 @MCM-41-MIPs) with good magnetic properties and specific recognition of echinacoside and acteoside was prepared by surface imprinting. Echinacoside and acteoside served as dual templates, 4-vinylpyridine (4-VP) was used as a functional monomer, the cross-linker was ethylene glycol dimethacrylate (EGDMA), and the selected initiator was azobisisobutyronitrile (AIBN). The prepared Fe 3 O 4 @MCM-41-MIPs were applied to the selective separation and enrichment of echinacoside and acteoside from Cistanche deserticola Y. C. Ma (C. deserticola). The resulting Fe 3 O 4 @MCM-41-MIPs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), laser particle size scanning and vibration sample magnetometry (VSM). The results of the isotherm adsorption experiment showed that the maximum adsorption capacities of Fe 3 O 4 @MCM-41-MIPs for echinacoside and acteoside were 6.02 and 1.63 mg·g-1, respectively, at 298 K. The pseudo-second-order reaction mechanism showed that the equilibrium adsorption capacities of Fe 3 O 4 @MCM-41-MIPs for echinacoside and acteoside were 4.81 and 0.93 mg·g-1, respectively. The characterization of Fe 3 O 4 @MCM-41-MIPs showed that the imprinted layer with dual-template molecules was wrapped on the outside of the carrier, and the obtained Fe 3 O 4 @MCM-41-MIPs showed good saturation magnetization, desirable capacity for echinacoside and acteoside adsorption, and satisfactory reuse (echinacoside and acteoside maintained relative adsorption rates of 97.5% and 95.8% after five cycles). After separation, the purities of echinacoside and acteoside were 33.50% and 27.00%, respectively. In addition, in the selective adsorption experiment, the synthesized Fe 3 O 4 @MCM-41-MIPs showed better selectivity for echinacoside and acteoside than their structural analogs. Therefore, this method proved to be sustainable, rapid and highly efficient for the separation and enrichment of echinacoside and acteoside. [Display omitted] • Fe 3 O 4 @MCM-41-MIPs based on dual-molecular was prepared and characterized. • Fe 3 O 4 @MCM-41-MIPs showed good selective extraction and enrichment for target compounds. • Fe 3 O 4 @MCM-41-MIPs exhibited a good magnetic property for rapid extraction. • Fe 3 O 4 @MCM-41-MIPs was proved to be simple, selective and recyclable material. [ABSTRACT FROM AUTHOR]