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Transition metal oxide nanomaterials (TMOs) have been adopted to produce reactive oxygen species (ROS) and adjust tumor microenvironment (TME) in cancer therapy. However, mono-modal treatment and the incompatibility of biological enzyme both hampered the therapeutic effect. Herein, we developed a multimodal TMO-based nanoplatform that the ultrathin Ti3C2 nanosheets were attached onto the MnFe2O4 nanoparticles self-assembled by applying chitosan as a chemical crosslinker to construct an interfacial Schottky junction, Ti3C2@Chitosan-MnFe2O4 (TC@Ch-MFO), achieving improved ROS generation as well as optimized biocompatibility. This heterojunction can controllably catalyze hydrogen peroxide (H2O2) to generate O2 and deplete the overexpressed glutathione (GSH) levels in hypoxic TME, which realizes the chemodynamic therapy (CDT) by cyclized Fenton reaction under NIR excitation. TC@Ch-MFO also constructs a multimodal treatment nanoplatform by introducing available high-efficiency photothermal agent (PTA), Ti3C2, for phtotheraml therapy (PTT). In addition, it simultaneously integrates the visualization with T1- and T2-weighting magnetic resonance imaging (MRI). The toxicity of TC@Ch-MFO to normal tissue cells is negligible. This platform could provide new insights into the development of multimoded synergistic nanoplatform for biological applications, especially breaking the shackles of MXenes merely used as a photo-thermal agent, adopting it to bioimaging sensor and drug loading.

Extraction or injection of charges through the interface in hybrid catalysts is a fascinating strategy for steering charge carrier transfer in solar energy conversion applications. Instead of interfacial charges regulation, we adopt intrinsic spontaneous polarization-modulated internal electric field to drive photo-generated carriers separation and transfer in both the bulk and surface for photocatalysis. Herein, we first report a series of nano-composites made of perovskite ferroelectric BiFe0.9Mn0.1O3 and orthorhombic phase α-MoO3 semiconductor (BFMO-xM, x = 0, 5%, 10%, 15%) via two-step thermal synthesis method. With × = 10%, the heterostructure exhibits significantly enhancement of optical response and photo-decomposion tetracycline capacity under sunlight compared with pure BFMO and M. The improved photocatalysis is attributed to the superimposed actions of the Z-scheme charge transfer through interface and the polarization field in BFMO for the anti-recombination of photo-excited electron-hole pairs. This work indeed offers a strategic design over multicomponent catalyst by consider the synergy of polarization charges and interfacial charge transmission for solar energy conversion.