1. Amelioration of radiation cystitis by tetrahedral framework nucleic acid nanostructures functionalized with quercetin.
- Author
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Wang, Wei, Yan, Ran, Lin, Lede, Peng, Liao, Xiong, Yang, Chen, Huiling, Gao, Xiaoshuai, Liu, Kun, Zhou, Liang, and Lin, Yunfeng
- Subjects
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NUCLEIC acids , *CYSTITIS , *OXIDATIVE stress , *NANOSTRUCTURES , *RADIATION - Abstract
• tFNA-Que can alleviate radiation-induced oxidative stress and inflammation. • tFNA-Que presents a straightforward and efficient synergistic delivery nano-system. Radiation cystitis (RC) has impacted millions globally with high morbidity and a dearth of effective strategies. Earlier research indicated that quercetin (Que) could alleviate radiation-induced bladder damage. However, Que's limited application arises from issues such as poor water solubility, rapid degradation, and low oral bioavailability. To address these challenges, a nano-system, named tFNA-Que, has been developed for Que delivery, utilizing the tetrahedral framework nucleic acid (tFNA). Due to the anti-inflammatory, antioxidant, and delivery capabilities of tFNA, it is purposefully designed as an efficient carrier for delivering Que. The tFNA-Que formulation exhibits an easily synthesized structure, stable performance, sustained release, good water solubility, robust cellular internalization ability, desirable biocompatibility, and biosafety. As a result, tFNA-Que can alleviate radiation-induced oxidative stress and inflammation while promoting angiogenesis in RC. In summary, the synthesis of tFNA-Que presents a straightforward and efficient synergistic delivery nano-system, making it as a promising candidate for RC treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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