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1. A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent.

Author

Shaikh A, Neeli PK, Singuru G, Panangipalli S, Banerjee R, Maddi SR, Thennati R, Bathula SR, and Kotamraju S

Subjects
Humans, Cell Line, Tumor, Cell Proliferation drug effects, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Umbelliferones chemistry, Umbelliferones pharmacology, RNA, Small Interfering chemistry, RNA, Small Interfering pharmacology
Abstract

Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.

Published
2021
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