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1. Trivalent metal complex geometry of the substrate governs cathepsin B enzymatic cleavage rate.

Author

Ahn SH, Iuliano JN, and Boros E

Subjects
Amino Acid Sequence, Cations chemistry, Chelating Agents chemistry, Enzyme Activation, Kinetics, Lysosomes chemistry, Metals chemistry, Molecular Conformation, Structure-Activity Relationship, Cathepsin B metabolism, Coordination Complexes chemistry, Coordination Complexes metabolism
Abstract

The lysosomal protease cathepsin B recognizes defined, short peptide sequences, providing means for effective, targeted drug release. Here, we show that the introduction of a coordination complex adjacent to the cleavage sequence allows us to tune enzymatic cleavage rate by varying the complexed, trivalent metal ion.

Published
2020
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