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An efficient and environmentally benign electrochemical oxidative radical C-H sulfonylation of arenes/heteroarenes was developed in this work. A series of significant diarylsulfones were prepared under mild catalyst- and exogenous-oxidant-free reaction conditions, which efficiently avoid the issues of desulfonylation or over-reduction of sulfonyl groups.

A new protocol for C–S bond formation was developed by selective cross-coupling between a thiyl radical and an isobutyronitrile radical. Using this strategy, a series of valuable α-alkylthionitrile derivatives were synthesized from basic starting materials. Preliminary mechanistic investigation was performed by EPR and XAFS, revealing that the transient thiyl radical could be stabilized by a copper catalyst to a persistent one. Therefore, on the basis of the persistent radical effect, selective radical–radical cross-coupling between the thiyl radical and the isobutyronitrile radical was achieved successfully in this work.

Environmentally benign iron catalysts promote a wide variety of chemical transformations; however, insight into the mechanism and active intermediates is far from satisfactory, and the main difficulties lie in directly "seeing" the active species under "live" catalytic conditions. Herein, an unknown sextet Ph(THF)FeCl

A novel palladium-catalyzed aerobic (1+2) annulation was developed for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. The palladation of Csp

Selective C–H bond activation and functionalization is an invaluable and eco-friendly tool for new chemical bond construction. Recently, great progress has been made in the highly selective ortho- and meta-C–H bond functionalization of arene derivatives. In contrast, the remote para-C–H bond functionalization still remains a challenge. Herein, an oxidation-induced strategy for para-selective C–H bond functionalization of iodobenzenes towards the synthesis of various useful asymmetric diaryl ethers was demonstrated. This strategy not only provides a novel method for para-C–H bond functionalization, but also proposes a general idea for the development of new, highly selective para-C–H functionalization reactions.