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Your search keyword '"Saroj Kumar Rout"' showing total 3 results
Start Over Author "Saroj Kumar Rout" Journal chemical communications (cambridge, england)
3 results on '"Saroj Kumar Rout"'

1. A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

Author

Gilles Marghem, Tom Leyssens, Olivier Riant, Junjie Lan, and Saroj Kumar Rout

Subjects
Bicyclic molecule, 010405 organic chemistry, Chemistry, Process synthesis, Metals and Alloys, General Chemistry, Metabolic stability, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Pentane, chemistry.chemical_compound, Materials Chemistry, Ceramics and Composites, Molecule, Moiety, Xanthate, Bioisostere
Abstract

Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit into a chemical entity remains a significant challenge from a synthetic point of view. Here, we have presented a new approach for the installation of the BCP unit on the xanthate moiety by means of a radical exchange process.

Published
2019

2. A metal free domino synthesis of 3-aroylindoles via two sp³ C-H activation

Author

Anupal, Gogoi, Anju, Modi, Srimanta, Guin, Saroj Kumar, Rout, Debapratim, Das, and Bhisma K, Patel

Abstract

A metal free synthesis of 3-aroylindole involving two sp(3) C-H activation has been achieved starting from o-alkynyl-N,N-dialkylamines using catalyst TBAI and oxidant TBHP.

Published
2014

3. Easy access to benzylic esters directly from alkyl benzenes under metal-free conditions

Author

Ganesh Majji, Anupal Gogoi, Srimanta Guin, Saroj Kumar Rout, and Bhisma K. Patel

Subjects
chemistry.chemical_classification, Chemistry, Metals and Alloys, General Chemistry, Carbocation, Medicinal chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Metal free, Materials Chemistry, Ceramics and Composites, Organic chemistry, Alkyl
Abstract

An efficient metal free protocol has been developed for the synthesis of benzylic esters via a cross dehydrogenative coupling (CDC) involving alkylbenzene(s) as a self- or as a cross-coupling partner(s) via the intermediacy of Ar-COOH and the benzylic carbocation obtained from the other half of the alkylbenzene; both symmetrical as well as unsymmetrical esters can be prepared using Bu4NI and TBHP.

Published
2013

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