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Your search keyword '"Hong-Wen Liu"' showing total 6 results
Start Over Author "Hong-Wen Liu" Journal chemical communications (cambridge, england)
6 results on '"Hong-Wen Liu"'

1. A two-photon fluorescence self-reporting black phosphorus nanoprobe for the

Author

Kesong, Guan, Peng, Wang, Fang, Zhou, Youjuan, Wang, Hong-Wen, Liu, Qingji, Xie, Guosheng, Song, Xia, Yin, Shuangyan, Huan, and Xiao-Bing, Zhang

Subjects
Photons, Photosensitizing Agents, Molecular Structure, Singlet Oxygen, Cell Survival, Infrared Rays, Optical Imaging, Mammary Neoplasms, Experimental, Antineoplastic Agents, Phosphorus, Fluorescence, Mice, Photochemotherapy, Cell Line, Tumor, Animals, Humans, Precision Medicine, Reactive Oxygen Species, Fluorescent Dyes
Abstract

The in situ and real-time supervision of reactive oxygen species (ROS) generated during photodynamic therapy (PDT) is of great significance for lessening nonspecific damage and guiding personalized therapy. However, photosensitizers frequently fail to deliver successful treatment accompanying the ROS-related imaging signals produced, impeding simple treatment outcome predictions and therapeutic schedule adjustments. Here, we report a two-photon fluorescence self-reporting strategy for the in situ and real-time monitoring of treatment response via a novel black phosphorus-based two-photon nanoprobe (TPBP). TPBP effectively generated singlet oxygen (1O2) under near-infrared laser irradiation for PDT, and 1O2 stimulated a two-photon molecule to emit fluorescence signals for feedback of 1O2 generation, which facilitated the regulation of treatment parameters to achieve precise and personalized medicine in deep tissue.

Published
2020

2. Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe

Author

Lin Yuan, Jie Yuan, Weihong Tan, Xiao-Bing Zhang, Haiyang Zhang, Hong-Wen Liu, Lili Teng, and Xiaofeng Lou

Subjects
inorganic chemicals, Infrared, Infrared Rays, Catalysis, Fluorescence, Cell Line, Absorbance, Photoacoustic Techniques, chemistry.chemical_compound, Mice, Nuclear magnetic resonance, Peroxynitrous Acid, Materials Chemistry, medicine, Fluorescence Resonance Energy Transfer, Animals, Humans, Molecular Structure, Metals and Alloys, Acute kidney injury, General Chemistry, Acute Kidney Injury, medicine.disease, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Förster resonance energy transfer, chemistry, Molecular Probes, Injections, Intravenous, cardiovascular system, Ceramics and Composites, Cisplatin, Molecular probe, Peroxynitrite
Abstract

A FRET-based probe for mapping the fluctuation of ONOO− in cisplatin-induced acute kidney injury was constructed. It exhibits ratiometric near infrared fluorescence and a dramatic decrease of its peak absorbance at 719 nm upon addition of ONOO− that is converted into remarkable signal changes in fluorescence and photoacoustic images respectively.

Published
2020

3. pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation

Author

Xiao-Bing Zhang, Hong-Wen Liu, Lin Yuan, Shuai Xu, Tian-Bing Ren, Haowei Guo, Xiaofeng Lou, Chengyan Xu, Yongchao Liu, and Lili Teng

Subjects
Boron Compounds, Light, Cell Survival, Transplantation, Heterologous, Heterologous, macromolecular substances, Stimulus (physiology), Catalysis, Tumor ablation, chemistry.chemical_compound, Mice, Cell Line, Tumor, Neoplasms, otorhinolaryngologic diseases, Materials Chemistry, Animals, Humans, Mice, Inbred BALB C, Photosensitizing Agents, Metals and Alloys, General Chemistry, Photothermal therapy, Hydrogen-Ion Concentration, Phototherapy, In vitro, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, carbohydrates (lipids), Transplantation, stomatognathic diseases, chemistry, Photochemotherapy, Cell culture, Ceramics and Composites, Cancer research, bacteria, BODIPY
Abstract

Herein, we report a pH stimulus-disaggregated BODIPY sensitizer (PTS) with low background-toxicity for achieving activated photodynamic/photothermal tumor therapy. Both the photodynamic and photothermal properties of PTS can be activated under acidic conditions, and PTS exhibits excellent antitumor properties, which is revealed by both in vitro and in vivo tests.

Published
2020

4. Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity

Author

Hong-Wen Liu, Jinping Wang, Xiao-Bing Zhang, Lin Yuan, Dan Cheng, Longmin Zhu, Peng Wang, and Mei Chen

Subjects
Stereoisomerism, Catalysis, Fluorescence, Cell Line, Rhodamine, chemistry.chemical_compound, Lactones, In vivo, Limit of Detection, Sense (molecular biology), Microscopy, Materials Chemistry, Animals, Humans, Organosilicon Compounds, Fluorescent Dyes, chemistry.chemical_classification, Mice, Inbred BALB C, Microscopy, Confocal, Rhodamines, Near-infrared spectroscopy, Metals and Alloys, General Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Hypochlorous Acid, chemistry, Microscopy, Fluorescence, Drug Design, Ceramics and Composites, Biophysics, Kidney Diseases, Gentamicins, Lysosomes, Lactone
Abstract

A highly selective lysosome-targeting NIR fluorescent probe (Lyso-SiR-2S) for HOCl was constructed based on Si-rhodamine B spirodithiolactone. This probe was very effectively employed to sense HOCl produced in various living cells and to visualize fluctuations of endogenous HOCl resulting from GEN-induced acute kidney injury in vivo for the first time.

Published
2019

5. A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues

Author

Xiaoyan Zhu, Xiao-Bing Zhang, Guo-jiang Mao, Weihong Tan, Mengyi Xiong, Hong-Wen Liu, Xiaoxiao Hu, Liyi Zhou, and Jing Zhang

Subjects
Diagnostic Imaging, Cells, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, Two-photon excitation microscopy, Materials Chemistry, Medical imaging, Fluorescence Resonance Energy Transfer, Humans, Nitrogen oxides, Fluorescent Dyes, Photons, Metals and Alloys, Nitroxyl, General Chemistry, 021001 nanoscience & nanotechnology, Fluorescence, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Förster resonance energy transfer, chemistry, Ceramics and Composites, Biophysics, Nitrogen Oxides, 0210 nano-technology, HeLa Cells
Abstract

A FRET-based two-photon fluorescent probe, , which exhibited a fast and high selective ratiometric response to nitroxyl, was first proposed. was successfully applied to two-photon dual-channel imaging of nitroxyl in living cells and tissues with less cross-talk between channels and satisfactory deep-tissue imaging depth.

Published
2015

6. A highly sensitive and reductant-resistant fluorescent probe for nitroxyl in aqueous solution and serum

Author

Xiao-Bing Zhang, Hong-Wen Liu, Xue-Lin Shi, Liyi Zhou, Yong-Xiang Wu, Weihong Tan, Ru-Qin Yu, and Guo-Jiang Mao

Subjects
Inorganic chemistry, Mass spectrometry, Catalysis, chemistry.chemical_compound, Materials Chemistry, Animals, Bovine serum albumin, Fluorescent Dyes, Aqueous solution, biology, Metals and Alloys, Water, Nitroxyl, General Chemistry, Coumarin, Fluorescence, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Highly sensitive, Spectrometry, Fluorescence, chemistry, Reducing Agents, Ceramics and Composites, biology.protein, Water chemistry, Cattle, Nitrogen Oxides
Abstract

A novel coumarin-based fluorescent probe, P-CM, for quantitative detection of nitroxyl (HNO) was developed. P-CM exhibits a selective response to HNO over other biological reductants and was also applied for quantitative detection of HNO in bovine serum with satisfactory results.

Published
2014

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