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Start Over Author "PuQin" Journal chemical communications
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2. The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides

Author

Nan Zhang, Chunyan Tan, Yufen Zhao, Pei-Zhuo Zhang, Yuyang Jiang, and Puqin Cai

Subjects
Genetic enhancement, Oligonucleotides, Catalysis, Escherichia coli, Materials Chemistry, medicine, Animals, Humans, Prodrugs, Hypoxia, Phosphoramidite, Base Sequence, Staining and Labeling, Oligonucleotide, Chemistry, Metals and Alloys, General Chemistry, Nitroreductases, Hypoxia (medical), Prodrug, In vitro, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Design synthesis, Biochemistry, Drug Design, Ceramics and Composites, Cattle, Fluorescein, medicine.symptom, Selectivity, HeLa Cells
Abstract

Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.

Published
2009
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