1. Spatially resolved coding of λ-orthogonal hydrogels by laser lithography
- Author
-
Kilian N. R. Wuest, Martin Wegener, Christopher Barner-Kowollik, Eva Blasco, Martina H. Stenzel, Hongxu Lu, and Rhiannon Batchelor
- Subjects
Materials science ,Pyrazoline ,macromolecular substances ,02 engineering and technology ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,PEG ratio ,Materials Chemistry ,Spatially resolved ,technology, industry, and agriculture ,Metals and Alloys ,General Chemistry ,021001 nanoscience & nanotechnology ,Fluorescence ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Self-healing hydrogels ,Ceramics and Composites ,Reaction system ,0210 nano-technology ,Maskless lithography ,Visible spectrum - Abstract
A λ-orthogonal reaction system is introduced, where visible light induced radical thiol-ene and UV light induced NITEC (Nitrile-Imine mediated Tetrazole-Ene Conjugation) ligations are consecutively employed to fabricate and functionalize PEG-based hydrogels. The fluorescent pyrazoline cycloadducts from the NITEC reaction are exploited to visualize the written structures within the hydrogels as well as to attach RGD containing functional groups to promote spatially resolved cell attachment on the hydrogel surface.
- Published
- 2018