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Continuous Friedel–Crafts alkylation of mesitylene, C6H3Me3, and anisole, C6H5OMe, with propene or propan-2-ol has been carried out in supercritical propene or CO2 using a heterogeneous polysiloxane-supported solid acid Deloxan® catalyst in a small fixed bed reactor (10 ml volume); 100% selectivity for mono-alkylated products with 50% conversion could be obtained by adjusting the reaction parameters, e.g. temperature, pressure, flow rates, etc.

A small flow reactor (5 ml volume) is used for continuous hydrogenation in supercritical CO2 or propane with polysiloxane-supported noble metal catalysts; a wide range of organic functionalities can be hydrogenated with good throughput (up to 1200 ml h-1 in favourable cases) and the various parameters (temperature, pressure, concentration of H2, etc.) can be controlled independently to optimise the selectivity for a particular product.