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Your search keyword '"Dall'angelo A"' showing total 5 results
Start Over Author "Dall'angelo A" Journal chemical communications
5 results on '"Dall'angelo A"'

1. Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway

Author

Claudia Clemente, Nicholas Johnson, Xiaodan Ouyang, Rafael V. Popin, Sergio Dall'Angelo, Matti Wahlsten, Jouni Jokela, Alessandro Colombano, Brunello Nardone, David P. Fewer, Wael E. Houssen, Institute of Biotechnology, Department of Food and Nutrition, Department of Microbiology, Faculty of Agriculture and Forestry, Cyanobacteria research, Helsinki Institute of Sustainability Science (HELSUS), and Microbial Natural Products

Subjects
HETEROCYCLIZATION, PROTEINS, Metals and Alloys, ENABLES, General Chemistry, Catalysis, TRYPTOPHAN, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, DRUG DISCOVERY, Materials Chemistry, Ceramics and Composites, 1182 Biochemistry, cell and molecular biology, MACROCYCLASE, ENZYMES, CYCLIC PEPTIDE
Abstract

Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-D-Arg-containing autum-nalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets the guanidinium moiety in arginine and homoarginine and is a useful tool for biotechnological applications.

Published
2022

3. [18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging

Author

David O'Hagan, Lutz Frank Schweiger, Xiang-Guo Li, Sergio Dall'Angelo, and Matteo Zanda

Subjects
Fluorine Radioisotopes, Carcinoma, Hepatocellular, Peptide, Ligands, ta3111, Catalysis, chemistry.chemical_compound, Fluorodeoxyglucose F18, Labelling, Oximes, Materials Chemistry, medicine, Humans, Receptor, PAR-2, ta116, ta317, Reaction conditions, chemistry.chemical_classification, Bioconjugation, medicine.diagnostic_test, Chemistry, Liver Neoplasms, Metals and Alloys, General Chemistry, Pet imaging, Hydrogen-Ion Concentration, Ligand (biochemistry), Combinatorial chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Deoxyribose, Positron emission tomography, Positron-Emission Tomography, Ceramics and Composites, Peptides
Abstract

[(18)F]-5-Fluoro-5-deoxyribose ([(18)F]-FDR) conjugates much more rapidly than [(18)F]-FDG under mild reaction conditions to peptides and offers new prospects for mild and rapid bioconjugation for fluorine-18 labelling in PET imaging.

Published
2012

5. 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease.

Author

Calamai, Elisa, Dall'Angelo, Sergio, Koss, David, Domarkas, Juozas, McCarthy, Timothy J., Mingarelli, Marco, Riedel, Gernot, Schweiger, Lutz F., Welch, Andy, Platt, Bettina, and Zanda, Matteo

Subjects
*BARBITURATES, *ALZHEIMER'S disease, *GABA receptors, *BRAIN imaging, *DRUG efficacy, *TRANSGENIC mice, *AMYLOID
Abstract

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(ii) indicator. [ABSTRACT FROM AUTHOR]

Published
2013
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