1. Dendrimeric tetravalent ligands for the serotonin-gated ion channel.
- Author
-
Paolino, Marco, Giuliani, Germano, Anzini, Maurizio, Donati, Alessandro, Cappelli, Andrea, Mennuni, Laura, Lanza, Marco, Caselli, Gianfranco, Galimberti, Chiara, and Menziani, Maria Cristina
- Subjects
- *
DENDRIMERS , *MULTIVALENT molecules , *MOLECULAR structure of ligands , *LIGAND-gated ion channels , *SEROTONIN receptors - Abstract
Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar Ki value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF