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Your search keyword '"Savelieff, Masha G"' showing total 1 results
Start Over Author "Savelieff, Masha G" Search Limiters Peer Reviewed Topic alzheimer's disease Journal chemical communications
1 results on '"Savelieff, Masha G"'

1. A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.

Author

Savelieff, Masha G., Yuzhong Liu, Senthamarai, Russell R. P., Korshavn, Kyle J., Hyuck Jin Lee, Ramamoorthy, Ayyalusamy, and Mi Hee Lim

Subjects
*ALZHEIMER'S disease, *AMYLOID, *COPPER ions, *ZINC ions, *ETIOLOGY of diseases, *DISEASE progression
Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ. [ABSTRACT FROM AUTHOR]

Published
2014
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