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Your search keyword '"Soskic V"' showing total 2 results
Start Over Author "Soskic V" Journal chemical biology drug design
2 results on '"Soskic V"'

1. Identification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides.

Author

Rajacic SK, Schwall G, Penjisevic J, Andric D, Sukalovic V, and Soskic V

Subjects
Amides metabolism, Animals, Brain enzymology, Ferrochelatase chemistry, NAD(P)H Dehydrogenase (Quinone) chemistry, Neuroprotective Agents metabolism, Rats, Amides chemistry, Ferrochelatase metabolism, NAD(P)H Dehydrogenase (Quinone) metabolism, Neuroprotective Agents chemistry, Piperazine chemistry
Abstract

Affinity chromatography was used to identify potential cellular targets that are responsible for neuroprotective activity of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. Active and inactive representatives of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides bearing an extended linker were synthesized and immobilized on an agarose-based matrix. This was followed by the identification of specifically bound proteins isolated out of the whole rat brain extract. Inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) was identified as candidates for cellular targets., (© 2018 John Wiley & Sons A/S.)

Published
2018
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2. Molecular modeling of 5HT2A receptor - arylpiperazine ligands interactions.

Author

Sencanski M, Sukalovic V, Shakib K, Soskic V, Dosen-Micovic L, and Kostic-Rajacic S

Subjects
Binding Sites, Ligands, Molecular Docking Simulation, Protein Binding, Models, Molecular, Piperazines chemistry, Receptor, Serotonin, 5-HT2A chemistry
Abstract

In this paper, we report the molecular modeling of the 5HT2A receptor and the molecular docking of arylpiperazine-like ligands. The focus of the research was on explaining the effects the ligand structure has on the binding properties of the 5HT2A receptor and on the key interactions between the ligands and the receptor-binding site. To see what the receptor–ligand interactions were, various substituents were introduced in one part of the ligand, keeping the rest unchanged. In this way, using a docking analysis on the proposed 5HT2A receptor model, we identified key receptor–ligand interactions and determined their properties. Those properties were correlated with experimentally determined binding affinities in order to determine the structure to activity relationship of the examined compounds.

Published
2014
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