Search

Your search keyword '"Suthum Intararuangsorn"' showing total 2 results
Start Over Author "Suthum Intararuangsorn" Journal chemical and pharmaceutical bulletin
2 results on '"Suthum Intararuangsorn"'

1. Structure Elucidation of Glycosidic Antibiotics, Glykenins, from Basidiomycetes sp. IV. Structure of Glykenin III

Author

Makoto Suzuki, Yuji Mori, Vithaya Meevootisom, Fumiko Nishida, Suthum Intararuangsorn, Timothy W. Flegel, and Yodhathai Thebtaranonth

Subjects
chemistry.chemical_classification, Strain (chemistry), Stereochemistry, Glycoside, Glycosidic bond, General Chemistry, General Medicine, Secondary ion mass spectrometry, chemistry, Drug Discovery, Molecule, Trisaccharide, Two-dimensional nuclear magnetic resonance spectroscopy, Antibacterial agent
Abstract

Three new glycosidic antibiotics, glykenin (GK)-III A, B, and C (2a-c), were isolated as a mixture from a strain of Basidiomycetes sp. and identified as glycosides of C26-fatty acids and a diacetylated trisaccharide composed of glucose and two xyloses. The locations of the two acetyl groups were elucidated by secondary ion mass spectrometry (SIMS), double quantum filter (DQF), and relayed chemical shift correlation spectroscopy (COSY) spectral analysis.

Published
1991
Full Text
View/download PDF

2. Structure elucidation of glycosidic antibiotics, glykenins, from Basidiomycetes sp. II. Absolute structures of unusual polyhydroxylated C26-fatty acids, aglycones of glykenins

Author

Yuji Mori, Vithaya Meevootisom, Sayuri Isobe, Suthum Intararuangsorn, Timothy W. Flegel, Makoto Suzuki, Yodhathai Thebtaranonth, Takeyuki Furuse, Naoko Rokkaku, and Fumiko Nishida

Subjects
chemistry.chemical_classification, Chemical transformation, Stereochemistry, Enantioselective synthesis, Absolute configuration, Absolute (perfumery), Glycosidic bond, General Chemistry, General Medicine, chemistry.chemical_compound, Aglycone, chemistry, Drug Discovery, Organic chemistry, Aliphatic compound, Octane
Abstract

The structures of three aglycones of glykenins, produced by Basidiomycetes sp., were determined to be (2S, 16R, 17S, 21R)-2, 16, 17, 21-, (2S, 17R, 18S, 22R)-2, 17, 18, 22-, and (2S, 17S, 18S, 22R)-2, 17, 18, 22-tetrahydroxyhexacosanoic acids (3a-c). The absolute configurations of two of the four hydroxy groups in 3a-c were established by chiral synthesis of the degradation products (6a-c and 7a-c). Chemical transformation of 3a-c to 6, 8-dioxabicyclo[3.2.1]octane derivatives (18-c) revealed the relative and absolute configurations of the acyclic 1, 2-diol moieties in 3a-c.

Published
1990
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results