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Start Over Author "Satoko Harada" Journal chemical and pharmaceutical bulletin
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1. Synthesis and Pharmacological Profile of a New Selective G Protein-Coupled Receptor 119 Agonist; 6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one

Author

Daisuke Kataoka, Nobuhide Watanabe, Toshiyuki Miyazawa, Megumi Inoue, Masafumi Torii, Masakazu Kogami, Mitsuhiro Makino, Masao Sakairi, Ryuji Okamoto, Satoko Harada, and Naoki Takahashi

Subjects
Male, Agonist, medicine.drug_class, Stereochemistry, Cell Line, Receptors, G-Protein-Coupled, Mice, Piperidines, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Rats, Wistar, Glucagon-like peptide 1 receptor, G protein-coupled receptor, Gastric emptying, Chemistry, General Chemistry, General Medicine, Glucose Tolerance Test, Rats, Mice, Inbred C57BL, GPR119, Indenes, Biochemistry, Glucagon receptor family, Isopropyl
Abstract

6-((2-Fluoro-3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propyl)amino)-2,3-dihydro-1H-inden-1-one is a potent drug-like G protein-coupled receptor 119 (GPR119) agonist. It is hoped that this compound would be instrumental in probing the pharmacological potential of GPR119 agonists.

Published
2012

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