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Your search keyword '"Sadakazu Yokomori"' showing total 4 results
Start Over Author "Sadakazu Yokomori" Journal chemical and pharmaceutical bulletin
4 results on '"Sadakazu Yokomori"'

1. Synthesis and Evaluation of Novel 2-Oxo-1,2-dihydro-3-quinolinecarboxamide Derivatives as Potent and Selective Serotonin 5-HT4 Receptor Agonists

Author

Chika Ito, Masaji Suzuki, Hajime Asanuma, Sadakazu Yokomori, Yoshihiko Isobe, Makoto Muramatsu, Yutaka Ohuchi, and Toshie Kaneko

Subjects
Male, Agonist, medicine.drug_class, Drug Evaluation, Preclinical, Chemical synthesis, Dogs, Drug Discovery, medicine, Animals, Structure–activity relationship, Serotonin 5-HT4 Receptor Agonists, Receptor, Gastric emptying, Chemistry, Spectrum Analysis, General Chemistry, General Medicine, Amides, Serotonin Receptor Agonists, Biochemistry, Receptors, Serotonin, Quinolines, Female, Receptors, Serotonin, 5-HT4, Serotonin, Gastrointestinal Motility, Endogenous agonist
Abstract

A series of 8'-substituted N-(endo-8-azabicyclo[3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1, 2-dihydro-3-quinolinecarboxamides were synthesized. The 5-HT4 receptor agonistic activity was evaluated using the isolated guinea pig ileum preparation. Of the compounds synthesized, N-(endo-8-(3-hydroxypropyl)-8-azabicyclo[3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1, 2-dihydro-3-quinolinecarboxamide (15a, TS-951) exhibited the most potent serotonin 5-HT4 receptor agonistic activity. This compound had a high affinity for the serotonin 5-HT4 receptor althought it had no affinities for other broad spectrum receptors. Furthermore, it remarkably enhanced gastrointestinal motility in conscious fed dogs without unfavorable effects that non-selective serotonin 5-HT4 receptor agonist has. TS-951 may be useful in improving gastrointestinal dysfunction.

Published
2001

2. Studies on the Constituents of Guang-Dou-Gen (the Root of Sophora subprostrata CHUN et T.CHEN). (5). Isolation of Two New Flavanones and Daidzein

Author

Kazuko Maezima, Manki Komatsu, Kunihiro Suzuki, Kazuaki Kyogoku, Katsuo Hatayama, and Sadakazu Yokomori

Subjects
chemistry.chemical_compound, Sophora, biology, Chemistry, Stereochemistry, Drug Discovery, Daidzein, General Chemistry, General Medicine, Spectral data, biology.organism_classification
Abstract

Two new flavanones, I and VII, and daidzein were isolated from Guang-Dou-Gen (the root of Sophora subprostrata CHUN et T.CHEN). Fom the spectral data and comparison with sophoranochromene and its derivative, the structure of I was established as 2-[{3'-hydroxy-2', 2'-dimethyl-8'-(3-methyl-2-butenyl)} chroman-6'-yl]-7-hydroxy-8-(3-methyl-2-butenyl) chroman-4-one. The structure of VII was formulated from the spectral data and biogenetic speculation as 2-[{2'-(1-hydroxy-1-methylethyl)-7'-(3-methyl-2-butenyl)-2'3'-dihydrobenzofuran}-5'-yl]-7-hydroxy-8-(3-mehtyl-2-butenyl) chroman-4-one.

Published
1973

4. Studies on the Constituents of Guang-Dou-Gen (the Root of Sophora subprostrata CHUN et T.CHEN). (6). Isolation of Two New Flavanones

Author

Kazuaki Kyogoku, Kunihiro Suzuki, Manki Komatsu, Katsuo Hatayama, Kazuko Maejima, and Sadakazu Yokomori

Subjects
chemistry.chemical_compound, Sophora, biology, Stereochemistry, Chemistry, Drug Discovery, General Chemistry, General Medicine, biology.organism_classification, Spectral data, Flavanone
Abstract

Two new flavanones were isolated from Guang-Dou-Gen (the root of Sophora subprostrata CHUN et T.CHEN) and their structures were established from their spectral data and comparison with the corresponding synthesized derivatives as 4', 7-dihydroxy-6, 8-bis(3-methyl-2-butenyl)flavanone (I), and 2-[(7'-hydroxy-2', 2'-dimethyl-2H-benzopyran)-6'-yl]-7-hydroxy-8-(3-methyl-2-butenyl)chroman-4-one (XI).

Published
1973

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