1. Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State
- Author
-
Pradeep K. Mandal, Béatrice Langlois d'Estaintot, Brice Kauffmann, Ivan Huc, Benoit Baptiste, Chimie et Biologie des Membranes et des Nanoobjets (CBMN), and Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Models, Molecular ,Stereochemistry ,Molecular Conformation ,010402 general chemistry ,Antiparallel (biochemistry) ,G-quadruplex ,Crystallography, X-Ray ,Ligands ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Tetramer ,[CHIM]Chemical Sciences ,A-DNA ,heterocyclic compounds ,Molecular Biology ,Oxytricha ,010405 organic chemistry ,Organic Chemistry ,Quinoline ,Foldamer ,Cationic polymerization ,DNA, Protozoan ,Amides ,3. Good health ,0104 chemical sciences ,G-Quadruplexes ,Crystallography ,chemistry ,Quinolines ,Molecular Medicine ,DNA - Abstract
Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G4 T4 G4 )2 with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4 T4 G4 )2 in the solid state are observed.
- Published
- 2016