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Start Over Author "Heleen M. den Hertog" Journal cerebrovascular diseases
5 results on '"Heleen M. den Hertog"'

1. Nonfocal Symptoms in Patients with Transient Ischemic Attack or Ischemic Stroke: Occurrence, Clinical Determinants, and Association with Cardiac History

Author

Heleen M. den Hertog, Diederik W.J. Dippel, P. J. A. M. Brouwers, Heleen A. Booij, Peter J. Koudstaal, Gerben J. J. Plas, Marjolein Brusse-Keizer, and Neurology

Subjects
Brain Infarction, Male, medicine.medical_specialty, Time Factors, Heart Diseases, Amnesia, 030204 cardiovascular system & hematology, Risk Assessment, Positive visual phenomena, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Atrial Fibrillation, Humans, Medicine, Outpatient clinic, In patient, Registries, cardiovascular diseases, Aged, business.industry, Atrial fibrillation, Middle Aged, Prognosis, medicine.disease, nervous system diseases, Stenosis, Neurology, Ischemic Attack, Transient, Relative risk, Cardiology, Etiology, Female, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Background: Transient ischemic attacks (TIAs) accompanied by nonfocal symptoms are associated with a higher risk of cardiovascular events, in particular cardiac events. Reported frequencies of TIAs accompanied by nonfocal symptoms range from 18 to 53%. We assessed the occurrence of nonfocal symptoms in patients with TIA or minor ischemic stroke in a neurological outpatient clinic in terms of clinical determinants, cardiac history, and atrial fibrillation (AF). Methods: We included 1,265 consecutive patients with TIA or minor stroke who visited the outpatient clinic. During these visits, we systematically asked for nonfocal symptoms. Nonfocal symptoms included decreased consciousness, amnesia, positive visual phenomena, non-rotatory dizziness, and paresthesias. Relative risks for the presence of nonfocal symptoms in relation to clinical determinants, AF, and cardiac history were calculated. Results: In 243 (19%) of 1,265 patients, TIA or minor ischemic stroke was accompanied by one or more nonfocal symptoms. Non-rotatory dizziness, paresthesia, and amnesia were the most common nonfocal symptoms. In patients with an event of the posterior circulation or obesity, the qualifying TIA or minor stroke was more frequently accompanied by nonfocal symptoms, and in patients with significant carotid stenosis, nonfocal symptoms occurred less frequently. AF was related only with amnesia. Conclusion: Nonfocal symptoms are present in one out of 5 patients with TIA or ischemic stroke, in particular when located in the posterior circulation. A cardiac history or AF was not directly related to nonfocal symptoms. A heterogeneous etiology is suggested.

Published
2016

2. Contents Vol. 42, 2016

Author

Christopher Beynon, Hyeong-Joong Yi, Xia Zhang, Zeljka Calic, Christina Hamisch, Paul J.A.M. Brouwers, Serge Timsit, Martin Griebe, Jijun Shi, Yanlin Zhang, Timolaos Rizos, Ji-Sung Lee, Bernt Harald Helleberg, Jae Min Kim, Gert J. de Borst, Adnan I. Qureshi, Soo Joo Lee, Boris Krischek, Gerben J. J. Plas, Markus A Möhlenbruch, Angela C Webster, Paola Forti, Diogo C Haussen, Michael Kettner, Fayyaz Orfi, Paul J. Nederkoorn, Qiao Han, Chunfeng Liu, Joon-Tae Kim, Joan Montaner, Carlotta Barbara, John A Oostema, Daniela Niemann, Iris Q. Grunwald, Mohammad Rauf Afzal, Shoujiang You, Güliz Acker, Valérie Martin, Huihui Liu, Mark Stroick, Tetsuro Ago, Mathew J. Reeves, Matthijs C. Brouwer, Tai Hwan Park, Thorsten Steiner, Y.B.W.E.M. Roos, Min Uk Jang, Richard I. Lindley, Rainer Kollmar, Helmuth Steinmetz, Jun Lee, Yoshinobu Wakisaka, Tae-Hee Cho, Druckerei Stückle, Hee-Joon Bae, Nauman Jahangir, Yong Ko, Laura Mechtouff, Wei Xuan, Takanari Kitazono, Marco Zoli, Jan-Dirk Vermeij, Roland Veltkamp, Dennis Cordato, Nathan Mewton, Christophe Gaudin, Leticia C. Rebello, Gerrit Brinker, Laurent Suissa, Michael G. Hennerici, Peter Schmiedek, Fabiola Maioli, Peter J. Koudstaal, Matthias Manitz, Beom Joon Kim, Young-Chai Ko, Anne Huibers, Djurre de Waard, Marc Fatar, Klaus Fassbender, Christian Foerch, Umut Yilmaz, Ryu Matsuo, Ekkehart Jenetzky, Philip B. Gorelick, Hanne Ellekjaer, Ahmed A Malik, Kyung Bok Lee, Junya Kuroda, Kyung-Ho Yu, Jiro Kitayama, Dae Hyun Kim, Jong-Moo Park, Oliver C. Singer, Günther Hedtmann, Ki-Hyun Cho, Mario Abruscato, Kyusik Kang, Stefan Helwig, Marcus Czabanka, Eric Greveson, Marjolein Brusse-Keizer, Choong Hyun Kim, Patrick J. Kelly, Peter Sander, Raul G Nogueira, Marco Timmer, Peter A. Ringleb, Andreas Ragoschke-Schumm, Adam Strzelczyk, Sven Thonke, Peter Vajkoczy, Chongke Zhong, M. Fareed K. Suri, Heleen A. Booij, Keun-Sik Hong, Diederik van de Beek, Moon-Ku Han, Pierre Suchon, Jun Hata, Björn Misselwitz, Yves Donazzolo, Juneyoung Lee, Young-Soo Kim, Lenka Schwindling, Stefan H. Kreisel, Seena Dehkharghani, Tobias Neumann-Haefelin, Elodie Ong, Jin Hwan Cheong, Oliver Josef Müller, Jae Kwan Cha, Masahiro Kamouchi, Yong-Jin Cho, Michel Ovize, Sung Il Sohn, Byung-Chul Lee, Willeke F. Westendorp, Safwan Roumia, Mi Sun Oh, Michael Reiner, Vincent Larrue, Trevor Carle, Jihoon Kang, Dana Farahmand, Marie-Hélène Mahagne, Michael Frankel, Silke Walter, Martin Lesmeister, Gaetano Procaccianti, Jan C. Purrucker, Jonathan C. Craig, Anke Reihs, Svenja Schüler, Martin Gallagher, Valeria Nativio, Carina Hohmann, Mikayel Grigoryan, Jae Guk Kim, Benno Ikenberg, M. Laible, Heleen M. den Hertog, Waltraud Pfeilschifter, Jiaping Xu, Mathieu Zuber, Craig S. Anderson, Alison Halliday, Laurent Derex, Bent Indredavik, Jay Chol Choi, Hiromi Ishikawa, Yongjun Cao, Yvo B.W.E.M. Roos, Diederik W.J. Dippel, Jonathan A. Grossberg, Susanne Goerdes, Anastasios Mpotsaris, Philip Masson, Andreas Ferbert, Raf Brouns, Maura Coveri, Jeong-Ho Hong, Igor Sibon, Andrey Lima, Anna Mezzapesa, Alan Cass, Myung Hoon Han, Richard Bulbulia, Luigi Simonetti, Hiroshi Nakane, Pantelis Stavrinou, Zhichao Huang, Noriko Makihara, Mar Castellanos, Giuseppe Di Pasquale, Michele Domenico Spampinato, Roland Goldbrunner, Cecilia Cappelen-Smith, Sradha Kotwal, Wolfgang Reith, Marie-Christine Alessi, Angelika Alonso, Björn Reuter, Sang-Soon Park, Luyao Shi, Nadine Talia, Philippe Grosjean, and Norbert Nighoghossian

Subjects
Neurology, Traditional medicine, business.industry, Medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Published
2016

3. Prediabetes in Patients with Stroke or Transient Ischemic Attack: Prevalence, Risk and Clinical Management

Author

Adrienne A.M. Zandbergen, Heleen M. den Hertog, Peter J. Koudstaal, and Susanne Fonville

Subjects
Risk, medicine.medical_specialty, business.industry, medicine.disease, Impaired fasting glucose, Prediabetic State, Stroke, Impaired glucose tolerance, Clinical trial, Endocrinology, Insulin resistance, Neurology, Ischemic Attack, Transient, Diabetes mellitus, Internal medicine, Prevalence, Secondary Prevention, medicine, Humans, Neurology (clinical), Prediabetes, Risk factor, Cardiology and Cardiovascular Medicine, business
Abstract

Background: The prevalence of diabetes is emerging worldwide and is an important modifiable risk factor for stroke. People with prediabetes, an intermediate metabolic state between normal glucose metabolism and diabetes, have a tenfold increased risk of developing diabetes compared to those with a normal glucose metabolism. Prediabetes is comprised of impaired fasting glucose and/or impaired glucose tolerance and/or disturbed glycosylated hemoglobin levels. Prediabetes is highly prevalent in nondiabetic patients with transient ischemic attack (TIA) or ischemic stroke and nearly doubles their risk of stroke. This offers new options for secondary stroke prevention. Summary: Several detection methods exist for identifying (pre)diabetes, including fasting plasma glucose, 2-hour postload glucose and glycosylated hemoglobin levels. The concordance between these tests is not 100%, and they seem to be complementary. Screening for (pre)diabetes after stroke with fasting plasma glucose levels alone is insufficient, and 2-hour postload glucose and/or glycosylated hemoglobin levels should be determined as well. The prevalence of prediabetes in previously nondiabetic patients with a recent TIA or stroke ranges from 23 to 53%. This high prevalence in the acute phase after stroke can be transient or persistent, representing undiagnosed abnormal glucose metabolism. Impaired fasting glucose and impaired glucose tolerance have different pathophysiological mechanisms, including hepatic insulin resistance and muscle insulin resistance, respectively. Prediabetes seems to be a modest predictor for stroke, but doubles the risk for recurrent stroke. The relation between prediabetes after stroke and functional outcome is still unknown. However, it is most likely that prediabetes is a risk factor for a poor clinical outcome after stroke. There is a growing recognition that patients with prediabetes should be treated more aggressively. Both lifestyle and pharmacological interventions are possible treatment strategies. They are at least equally effective in preventing progression to diabetes. Lifestyle changes are difficult to maintain over a long period. The evidence of pharmacological interventions on stroke or other cardiovascular diseases is limited though and is still subject of several clinical trials. Conclusions: As the prevalence of prediabetes is growing rapidly, prediabetes might become one of the most important modifiable therapeutic targets in both primary and secondary prevention.

Published
2014

4. Contents Vol. 37, 2014

Author

Charles DeCarli, Pierre Etienne Leblanc, Yan Borné, Yukako Yazawa, Yasuhiro Ishibashi, Ying Kuen Cheung, Mitsuhiro Yoshita, Clinton B. Wright, Denis Ducreux, Joshua Z. Willey, Guillaume Saliou, Yeseon P. Moon, Druckerei Stückle, Yasushi Okada, Kozo Tanno, Christian Marescaux, Michael J. Lynn, Zoran Rumboldt, Peter J. Koudstaal, Fredrik Björklund, Anna Graipe, Heleen M. den Hertog, Akira Ogawa, Hisatomi Arima, Bernard Geny, Kenta Kawata, Eisuke Furui, Jean-Paul Armspach, Rémy Beaujeux, Catherine Ract, Valérie Lauer, Gunnar Engström, Kiyomi Sakata, Yuki Yoshida, John Berntsson, Shyam Prabhakaran, Kuniaki Ogasawara, Nobuyuki Yasui, Yasuhiro Hasegawa, Alejandro M. Brunser, Ryo Itabashi, Maria Matheus, Stina Jakobsson, Kazuyuki Nagatsuka, Hannah Gardener, Elisabet Zia, Motoyuki Nakamura, Olle Melander, Toshiyuki Uehara, Etsuro Mori, Thomas Mooe, Verónica V. Olavarría, Pablo M. Lavados, Marc I. Chimowitz, Kazuyoshi Itai, Stephane Heritier, Masaki Ohsawa, Kazuo Minematsu, Toshiyuki Onoda, Elena López-Cancio, Olivier Rouyer, Shoichiro Sato, Shinichi Omama, Mitchell S.V. Elkind, Satz Mengensatzproduktion, Daniel Huber, Bo Hedblad, Cécile Cauquil, Susanne Fonville, Valérie Wolff, Ralph L. Sacco, David S Liebeskind, Nicolas Meyer, Adrienne A.M. Zandbergen, Craig S. Anderson, Jose G. Romano, Tanya N. Turan, George Cotsonis, Paula Muñoz-Venturelli, Monica Manisor, and Marie Théaudin

Subjects
Neurology, Traditional medicine, business.industry, Medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business
Published
2014

5. Front and Back Matter

Author

Ryu Matsuo, Ekkehart Jenetzky, Adam Strzelczyk, Kyusik Kang, Heleen A. Booij, Helmuth Steinmetz, Yoshinobu Wakisaka, Yanlin Zhang, Jonathan A Grossberg, Vincent Larrue, Willeke F. Westendorp, Xia Zhang, Laura Mechtouff, Wei Xuan, Christina Hamisch, Roland Veltkamp, Peter J. Koudstaal, Zeljka Calic, Mohammad Rauf Afzal, Mathieu Zuber, Young-Soo Kim, Young-Chai Ko, Soo Joo Lee, Gerben J. J. Plas, Markus A Möhlenbruch, Gaetano Procaccianti, Chongke Zhong, Qiao Han, Iris Q. Grunwald, Anna Mezzapesa, Kyung Bok Lee, Stefan Helwig, Peter A. Ringleb, Timolaos Rizos, Fayyaz Orfi, Eric Greveson, Hiromi Ishikawa, Cecilia Cappelen-Smith, Yong Ko, Dennis Cordato, Silke Walter, Jun Hata, Björn Misselwitz, Gert J. de Borst, Serge Timsit, Dae Hyun Kim, Philippe Grosjean, Norbert Nighoghossian, Michael Reiner, Christopher Beynon, Hyeong-Joong Yi, Waltraud Pfeilschifter, Junya Kuroda, Günther Hedtmann, M. Fareed K. Suri, Jiro Kitayama, Mikayel Grigoryan, Tae-Hee Cho, Andreas Ferbert, Mark Stroick, Laurent Derex, Bent Indredavik, Peter Sander, Paola Forti, Diogo C Haussen, Sradha Kotwal, Anne Huibers, Wolfgang Reith, Björn Reuter, Patrick J. Kelly, Heleen M. den Hertog, Jae Min Kim, Jae Guk Kim, Richard I. Lindley, John A Oostema, Diederik van de Beek, Mathew J. Reeves, P. J. A. M. Brouwers, Sang-Soon Park, Umut Yilmaz, Luyao Shi, Oliver C. Singer, Michael Kettner, Chunfeng Liu, Y.B.W.E.M. Roos, Pantelis Stavrinou, Lenka Schwindling, Sung Il Sohn, Jiaping Xu, Joan Montaner, Nadine Talia, Craig S. Anderson, Nathan Mewton, Daniela Niemann, Christophe Gaudin, Diederik W.J. Dippel, Marco Zoli, Alison Halliday, Mario Abruscato, Raul G Nogueira, Peter Vajkoczy, Marie-Hélène Mahagne, Martin Griebe, Mi Sun Oh, Beom Joon Kim, Paul J. Nederkoorn, Fabiola Maioli, Djurre D. de Waard, Juneyoung Lee, Pierre Suchon, Gerrit Brinker, Stefan H. Kreisel, Svenja Schüler, Masahiro Kamouchi, Yong-Jin Cho, Ji-Sung Lee, Bernt Harald Helleberg, Christian Foerch, Jong-Moo Park, Roland Goldbrunner, Marie-Christine Alessi, Takanari Kitazono, Jay Chol Choi, Jijun Shi, Safwan Roumia, Güliz Acker, Marc Fatar, Michael Frankel, Klaus Fassbender, Boris Krischek, Trevor Carle, Valérie Martin, Jihoon Kang, Andreas Ragoschke-Schumm, Carlotta Barbara, Huihui Liu, Matthijs C. Brouwer, Thorsten Steiner, Jan C. Purrucker, Jonathan C. Craig, Anke Reihs, Marcus Czabanka, M. Laible, Benno Ikenberg, Min Uk Jang, Joon-Tae Kim, Angelika Alonso, Yongjun Cao, Hee-Joon Bae, Carina Hohmann, Susanne Goerdes, Angela C Webster, Richard Bulbulia, Adnan I Qureshi, Ki-Hyun Cho, Sven Thonke, Tetsuro Ago, Valeria Nativio, Rainer Kollmar, Shoujiang You, Byung Chul Lee, Philip B. Gorelick, Hanne Ellekjær, Choong Hyun Kim, Laurent Suissa, Michael G. Hennerici, Oliver Josef Müller, Jae Kwan Cha, Tobias Neumann-Haefelin, Tai Hwan Park, Hiroshi Nakane, Raf Brouns, Peter Schmiedek, Moon-Ku Han, Kyung-Ho Yu, Keun-Sik Hong, Jeong-Ho Hong, Dana Farahmand, Elodie Ong, Jin Hwan Cheong, Michel Ovize, Jun Lee, Martin Lesmeister, Jan-Dirk Vermeij, Myung Hoon Han, Alan Cass, Martin Gallagher, Marco Timmer, Luigi Simonetti, Marjolein Brusse-Keizer, Ahmed A Malik, Giuseppe Di Pasquale, Michele Domenico Spampinato, Matthias Manitz, Yves Donazzolo, Yvo B.W.E.M. Roos, Leticia C Rebello, Seena Dehkharghani, Zhichao Huang, Maura Coveri, Igor Sibon, Noriko Makihara, Andrey Lima, Mar Castellanos, Anastasios Mpotsaris, Philip Masson, Druckerei Stückle, and Nauman Jahangir

Subjects
Optics, Neurology, business.industry, Medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Front (military)
Published
2013

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